Heterogeneous films of ionotropic hydrogels fabricated from delivery templates of patterned paper.
Heterogeneous films of ionotropic hydrogels fabricated from delivery templates of patterned paper.
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DOI：
10.1021/am900340m
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发表时间：
2009-08
影响因子：
9.5
通讯作者：
Whitesides, George M.
中科院分区：
文献类型：
--
作者：
Bracher, Paul J.;Gupta, Malancha;Mack, Eric T.;Whitesides, George M.
递送模板的使用使得可以制造离子型水凝胶的成形的、毫米厚的不均匀图案化的膜。这些结构包括由不同离子（例如，海藻酸与Ca 2+和Fe 3+交联）和单一交联离子浓度的阶梯梯度模式。输送模板由堆叠的色谱纸组成，色谱纸上有疏水屏障图案（防水胶带、透明膜或彩色激光打印机沉积的墨粉）。每一层纸都是不同的交联离子溶液的储存器，而疏水屏障则防止相邻纸张上的溶液混合。穿过片材切割的孔将交联离子的不同溶液暴露于模板的表面。具有由顺磁性离子交联的水凝胶的成形区域的膜可以用条形磁体定向。用于交联凝胶的阳离子的浓度的变化可以控制膜的机械性能：对于由用不同浓度的Fe 3+交联的区域组成的单一藻酸盐膜，用高浓度的Fe 3+交联的区域比用低浓度的Fe 3+交联的区域更刚性。异质水凝胶膜可用于以各种2-D设计培养细菌。用于交联聚合物的有毒和无毒离子的模式决定了E.膜内的大肠杆菌。
The use of delivery templates makes it possible to fabricate shaped, millimeter-thick heterogeneously patterned films of ionotropic hydrogels. These structures include 2-D patterns of a polymer cross-linked by different ions (e.g., alginic acid cross-linked with Ca2+ and Fe3+) and patterns of step-gradients in the concentration of a single cross-linking ion. The delivery templates consist of stacked sheets of chromatography paper patterned with hydrophobic barriers (waterproof tape, transparency film, or toner deposited by a color laser printer). Each layer of paper serves as a reservoir for a different solution of cross-linking ions, while the hydrophobic barriers prevent solutions on adjacent sheets from mixing. Holes cut through the sheets expose different solutions of cross-linking ions to the surface of the templates. Films with shaped regions of hydrogels cross-linked by paramagnetic ions can be oriented with a bar magnet. Variations in the concentrations of cations used to cross-link the gel can control the mechanical properties of the film: for single alginate films composed of areas cross-linked with different concentrations of Fe3+, the regions cross-linked with high concentrations of Fe3+ are more rigid than regions cross-linked with low concentrations of Fe3+. The heterogeneous hydrogel films can be used to culture bacteria in various 2-D designs. The pattern of toxic and nontoxic ions used to cross-link the polymer determines the pattern of viable colonies of E. coli within the film.
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影响因子：
64.8
作者：
Alon, U;Surette, MG;Leibler, S
通讯作者：
Leibler, S
影响因子：
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作者：
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41.2
作者：
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通讯作者：
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