Effects of dopamine depletion on network entropy in the external globus pallidus.
Effects of dopamine depletion on network entropy in the external globus pallidus.
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DOI：
10.1152/jn.00344.2009
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发表时间：
2009-08
影响因子：
2.5
通讯作者：
Averbeck BB
中科院分区：
文献类型：
--
作者：
Cruz AV;Mallet N;Magill PJ;Brown P;Averbeck BB
帕金森氏病(PD)患者皮质-基底神经节环路中的多巴胺缺乏严重干扰了运动和认知。经典模型将帕金森病功能障碍与基底节神经元放电率的变化联系起来。然而，神经活动的其他动力学方面的干扰也很常见。因此，考虑到不适当的放电率和其他动力学因素，并确定在局部放电过程中发生的这些神经回路的属性变化如何影响信息编码，是当务之急。在这里，我们研究了慢性多巴胺耗竭前后大鼠苍白球外区(GPE)的活体网络动力学。多巴胺耗竭导致GPE神经元放电频率降低，β频段(13-30赫兹)的同步网络振荡增加。使用Logistic回归模型，我们确定了这些因素对网络熵的组合和单独影响，网络熵是信息编码能力上限的衡量标准。重要的是，在多巴胺缺乏的大鼠中，这些特征的变化导致了GPE网络熵的显著降低。发电率的变化对信息量的影响最大，同步性的变化也会降低网络层面的信息量。自相关性的变化往往会抵消这些影响，因为在对照动物中，自相关性降低的熵更大。因此，基底节网络中信息编码能力的降低可能是伴随帕金森病的行为缺陷的原因之一。
Dopamine depletion in cortical-basal ganglia circuits in Parkinson's disease (PD) grossly disturbs movement and cognition. Classic models relate Parkinsonian dysfunction to changes in firing rates of basal ganglia neurons. However, disturbances in other dynamics of neural activity are also common. Taking both inappropriate firing rates and other dynamics into account and determining how changes in the properties of these neural circuits that occur during PD impact on information coding are thus imperative. Here, we examined in vivo network dynamics in the external globus pallidus (GPe) of rats before and after chronic dopamine depletion. Dopamine depletion led to decreases in the firing rates of GPe neurons and increases in synchronized network oscillations in the β frequency (13–30 Hz) band. Using logistic regression models, we determined the combined and separate impacts of these factors on network entropy, a measure of the upper bound of information coding capacity. Importantly, changes in these features in dopamine-depleted rats led to a significant decrease in GPe network entropy. Changes in firing rates had the largest impact on entropy, with changes in synchrony also decreasing entropy at the network level. Changes in autocorrelations tended to offset these effects because autocorrelations decreased entropy more in the control animals. Thus it is possible that reduced information coding capacity within basal ganglia networks may contribute to the behavioral deficits accompanying PD.
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影响因子：
14.5
作者：
Levy, R;Ashby, P;Dostrovsky, JO
通讯作者：
Dostrovsky, JO
影响因子：
64.8
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Kenet, T;Bibitchkov, D;Arieli, A
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Arieli, A
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2.5
作者：
Averbeck, Bruno B.;Lee, Daeyeol
通讯作者：
Lee, Daeyeol
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Boussaoud, D;Kermadi, I
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Kermadi, I
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作者：
Aizman, O;Brismar, H;Aperia, A
通讯作者：
Aperia, A