Seasonal Variation and Risk of Febrile Seizures: A Danish Nationwide Cohort Study.
Seasonal Variation and Risk of Febrile Seizures: A Danish Nationwide Cohort Study.
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DOI：
10.1159/000522065
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发表时间：
2022
影响因子：
5.7
通讯作者：
Christensen, Jakob
中科院分区：
文献类型：
--
作者：
Christensen, Kirstine Juul;Dreier, Julie W.;Skotte, Line;Feenstra, Bjarke;Grove, Jakob;Borglum, Anders D.;Mitrovic, Mitja;Cotsapas, Chris;Christensen, Jakob
热性惊厥的发作随季节而异。然而，以前没有评估过出生季节如何与年龄和热性惊厥的高峰风险相互作用，以及出生季节是否与5岁时热性惊厥的累积风险相关（即当儿童不再有热性惊厥的风险时）。我们确定了1977年至2011年期间在丹麦出生的所有3个月龄时存活的单胎儿童（N = 2，103，232）。我们使用丹麦民事登记系统来确定儿童的年龄和性别，并使用丹麦国家患者登记册来确定3个月至5岁因热性惊厥住院的儿童。随访于2016年12月31日结束，当时所有儿童均年满5岁。首次发热性惊厥入院的相对风险随日历月而变化;与8月（丹麦的夏季月份）相比，2月（丹麦的冬季月份）的风险增加一倍以上（HR：2.10（95% CI：2.03-2.18））。按出生月份划分的首次热性惊厥的年龄特异性发病率确定了11月出生的儿童中首次热性惊厥的最高发病率峰（在16个月大时，每100 000人月中有350例首次入院的热性惊厥发生率达到峰值），与7月出生的儿童相比，（在16个月龄时达到每100，000人月200例首次入院的热性惊厥的高峰发生率）。然而，五年前因热性惊厥入院的累积发生率与出生季节无关（3.69%（95%CI：3.64-3.74%）冬季出生，3.57%（95% CI：3.52-3.62%），春季出生，夏季出生3.55%（95% CI：3.50-3.59%），秋季出生3.64%（95% CI：3.59-3.69%）。该研究发现，首次热性惊厥发作和热性惊厥的年龄特异性高峰发病率存在显著的季节性变化。然而，出生季节和5岁时热性惊厥的累积发生率之间没有相关性，这表明易患热性惊厥的儿童最终会经历热性惊厥，而不管出生季节如何。
Onset of febrile seizures varies with calendar season. However, it has not previously been assessed, how season of birth interacts with age and peak risk of febrile seizures, and whether season of birth correlates with the cumulative risk of febrile seizures at 5 years of age (i.e. when children are no longer of risk of febrile seizures). We identified all singleton children born in Denmark between 1977 and 2011 who were alive at 3 months of age (N = 2,103,232). We used the Danish Civil Registration System to identify age and sex of the children and the Danish National Patient Register to identify children hospitalised with febrile seizures from 3 months to 5 years of age. Follow-up ended on 31 December 2016 when all children had reached 5 years of age. The relative risk of admission with a first febrile seizure varied with calendar month; in February (a winter month in Denmark) the risk was more than doubled (HR: 2.10 (95% CI: 2.03–2.18)) compared with August (a summer month in Denmark). The age-specific incidence of a first febrile seizure by birth month identified the highest peak incidence of a first febrile seizure among children born in November (reaching a peak incidence of 350 first admissions with a febrile seizure per 100,000 person months at age 16 months) as compared to children born in July (reaching a peak incidence of 200 first admissions with a febrile seizure per 100,000 person months at age 16 months). However, the cumulative incidence of any admission with febrile seizures before five years was not correlated with season of birth (3.69% (95% CI: 3.64–3.74%) for winter births, 3.57% (95% CI: 3.52–3.62%) for spring births, 3.55% (95% CI: 3.50–3.59%) for summer births and 3.64% (95% CI: 3.59–3.69%)) for fall births. The study found a significant seasonal variation in onset of the first febrile seizure and in the age-specific peak incidence of febrile seizures. However, there was no correlation between season of birth and cumulative incidence of febrile seizures at 5 years of age suggesting that children who are predisposed to febrile seizures will eventually go on to experience a febrile seizure regardless of season of birth.
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影响因子：
3.8
作者：
Mikkonen, Kirsi;Uhari, Matti;Rantala, Heikki
通讯作者：
Rantala, Heikki
DOI：
10.1001/archpedi.1997.02170410045006
发表时间：
1997-04-01
影响因子：
--
作者：
Berg, AT;Shinnar, S;Hauser, AW
通讯作者：
Hauser, AW
影响因子：
30.8
作者：
Feenstra, Bjarke;Pasternak, Bjorn;Geller, Frank;Carstensen, Lisbeth;Wang, Tongfei;Huang, Fen;Eitson, Jennifer L.;Hollegaard, Mads V.;Svanstrom, Henrik;Vestergaard, Mogens;Hougaard, David M.;Schoggins, John W.;Jan, Lily Yeh;Melbye, Mads;Hviid, Anders
通讯作者：
Hviid, Anders
影响因子：
5.1
作者：
Manfredini, R;Vergine, G;Borgna-Pignatti, C
通讯作者：
Borgna-Pignatti, C
影响因子：
105.7
作者：
SUNDERLAND, R;CARPENTER, RG;GARDNER, A
通讯作者：
GARDNER, A