Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage.
Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage.
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DOI：
10.1186/1743-7075-6-6
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发表时间：
2009-02-04
影响因子：
4.5
通讯作者：
Panton, Lynn B.
中科院分区：
文献类型：
--
作者：
Wilson, Jacob M.;Kim, Jeong-su;Lee, Sang-rok;Rathmacher, John A.;Dalmau, Brett;Kingsley, J. Derek;Koch, Heather;Manninen, Anssi H.;Saadat, Raz;Panton, Lynn B.
虽然长期补充β-羟基-β-甲基丁酸酯（HMB）（≥ 2周）可降低运动诱导的肌肉损伤，但尚未检查其急性或时间效应。本研究的目的是研究口服HMB补充对血清肌酸激酶（CK）、乳酸脱氢酶（LDH）、肌肉酸痛和最大随意收缩（MVC）的急性和时间效应。16名无阻力训练的男性（22 ± 2岁）被分配到HMB-Pre或HMB-Post组。在交叉设计中，所有受试者在右腿或左腿上进行了2次55次最大偏心膝关节伸展/屈曲收缩。HMB-Pre（N = 8）在运动前随机接受3克安慰剂或HMB，在运动后接受安慰剂。HMB-Post（N = 8）在运动前接受安慰剂，运动后接受3克HMB或安慰剂。在运动前、运动后8、24、48和72小时记录肌肉损伤测试。运动后，MVC减少，股四头肌和腿筋酸痛增加（p < 0.001）。尽管HMB-Pre在减轻四头肌疼痛方面接近显著性（p = 0.07），但没有时间×组效应。血清损伤指数增加，CK在48小时达到峰值（773%）（p < 0.001），LDH在72小时达到峰值（180%）（p < 0.001）。虽然HMB对CK和LDH无时间×组效应，但事后分析显示，仅HMB-Pre在运动后未显示LDH水平显著升高。我们的研究结果表明，HMB补充剂没有明显的急性或时间效应。然而，运动前摄入HMB似乎可以防止LDH的增加。
While chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction (MVC). Sixteen non-resistance trained men (22 ± 2 yrs) were assigned to HMB-Pre or HMB-Post groups. In a crossover design, all subjects performed 55 maximal eccentric knee extension/flexion contractions on 2 occasions on either the right or left leg. HMB-Pre (N = 8) randomly received 3 grams of either a placebo or HMB before and a placebo after exercise. HMB-Post (N = 8) received a placebo before and either 3 grams of HMB or a placebo after exercise. Muscle damage tests were recorded before, at 8, 24, 48, and 72 hrs post exercise. There was a reduction in MVC and an increase in soreness in the quadriceps and hamstrings following exercise (p < 0.001). Although HMB-Pre approached significance in attenuating soreness for the quadriceps (p = 0.07), there was no time × group effect. Serum indices of damage increased, peaking at 48 hrs for CK (773%) (p < 0.001) and 72 hrs for LDH (180%) (p < 0.001). While there were no time × group effects of HMB on CK and LDH, post hoc analysis revealed that only HMB-Pre showed no significant increase in LDH levels following exercise. Our findings suggest no clear acute or timing effects of HMB supplementation. However, consuming HMB before exercise appeared to prevent increases in LDH.
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DOI：
10.1123/ijsnem.15.4.413
发表时间：
2005-08-01
影响因子：
2.5
作者：
van Someren, KA;Edwards, AJ;Howatson, G
通讯作者：
Howatson, G
影响因子：
3.3
作者：
IVY, JL;KATZ, AL;COYLE, EF
通讯作者：
COYLE, EF
影响因子：
4.4
作者：
Jówko, E;Ostaszewski, P;Nissen, S
通讯作者：
Nissen, S
影响因子：
4.2
作者：
Vukovich, MD;Stubbs, NB;Bohlken, RM
通讯作者：
Bohlken, RM
DOI：
10.1249/01.mss.0000230123.68394.ff
发表时间：
2006-10-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Armstrong, Lawrence E.;Whittlesey, Michael J.;Maresh, Carl M.
通讯作者：
Maresh, Carl M.