Transcallosal white matter degradation detected with quantitative fiber tracking in alcoholic men and women: selective relations to dissociable functions.
Transcallosal white matter degradation detected with quantitative fiber tracking in alcoholic men and women: selective relations to dissociable functions.
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DOI：
10.1111/j.1530-0277.2010.01197.x
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Sullivan EV
中科院分区：
文献类型：
--
作者：
Pfefferbaum A;Rosenbloom MJ;Fama R;Sassoon SA;Sullivan EV
过量饮酒会对白质纤维产生不利影响，破坏神经元信号的传递。在这里，我们检查了六个经解剖定义的经胼胝体白质纤维束，并询问是否有任何束特别容易受到酒精的影响，白质完整性的哪个方面受到的影响最大，女性是否比男性更容易受到影响，以及特定束的损害是否与平衡、持续注意力、联想学习和精神运动功能的缺陷有关，这些缺陷通常在酗酒者中受到影响。扩散张量成像定量纤维跟踪评估了87名酗酒者（59名男性，28名女性）和88名健康对照者（42名男性，46名女性）6个经胼胝体白质束的完整性。测量包括定向扩散相干性（分数各向异性，FA）和扩散幅度，分别量化轴向（纵向；λL）和径向（横向；λT）扩散系数。还进行了数字符号测试和共济失调测试。酒精对胼胝体FA和λT均有负性影响，但感觉-运动束除外。没有证据表明女性比男性更容易受到酒精的影响。多元回归分析证实了双重分离：感觉运动束和顶束的高弥散性与较差的平衡性有关，但与精神运动速度无关，而前额叶束和颞束的高弥散性与较慢的精神运动速度有关，但与平衡无关。这项研究显示酒精对FA和径向扩散率的影响比轴向扩散率更强，提示髓磷脂降解，但没有证据表明女性比男性更容易受到酒精的影响。脑-行为关系的存在为酒精中毒相关的互质白质降解作为认知和运动障碍的基础提供了支持。双重分离的鉴定为选择性白质完整性在特定表现领域的作用提供了进一步的支持。
Excessive alcohol consumption can adversely affect white matter fibers and disrupt transmission of neuronal signals. Here, we examined six anatomically defined transcallosal white matter fiber bundles and asked whether any bundle was specifically vulnerable to alcohol, what aspect of white matter integrity was most affected, whether women were more vulnerable than men, and whether evidence of compromise in specific bundles was associated with deficits in balance, sustained attention, associative learning, and psychomotor function, commonly affected in alcoholics. Diffusion tensor imaging quantitative fiber tracking assessed integrity of six transcallosal white matter bundles in 87 alcoholics (59 men, 28 women) and 88 healthy controls (42 men, 46 women). Measures included orientational diffusion coherence (fractional anisotropy, FA) and magnitude of diffusion, quantified separately for axial (longitudinal; λL) and radial (transverse; λT) diffusivity. The Digit Symbol Test and a test of ataxia were also administered. Alcoholism negatively affected callosal FA and λT of all but the sensory-motor bundle. Women showed no evidence for greater vulnerability to alcohol than men. Multiple regression analyses confirmed a double dissociation: higher diffusivity in sensory-motor and parietal bundles was associated with poorer balance but not psychomotor speed, whereas higher diffusivity in prefrontal and temporal bundles was associated with slower psychomotor speed but not balance. This study revealed stronger alcohol effects for FA and radial diffusivity than axial diffusivity, suggesting myelin degradation, but no evidence for greater vulnerability to alcohol in women than men. The presence of brain-behavior relationships provides support for the role of alcoholism-related commissural white matter degradation as a substrate of cognitive and motor impairment. Identification of a double dissociation provides further support for the role of selective white matter integrity in specific domains of performance.
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影响因子：
--
作者：
Agartz, I;Momenan, R;Hommer, DW
通讯作者：
Hommer, DW
影响因子：
2.3
作者：
Cardenas, VA;Studholme, C;Weiner, MW
通讯作者：
Weiner, MW
影响因子：
4.2
作者：
Durazzo, Timothy C.;Cardenas, Valerie A.;Meyerhoff, Dieter J.
通讯作者：
Meyerhoff, Dieter J.
DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
影响因子：
2.2
作者：
GLOSSER, G;BUTTERS, N;KAPLAN, E
通讯作者：
KAPLAN, E