A multidimensional approach to understanding the emergence of sex differences in internalizing symptoms in adolescence.
A multidimensional approach to understanding the emergence of sex differences in internalizing symptoms in adolescence.
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DOI：
10.1016/j.dcn.2022.101182
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发表时间：
2022-12
影响因子：
4.7
通讯作者：
Yip, Sarah W.
中科院分区：
文献类型：
--
作者：
Serio, Bianca;Kohler, Robert;Ye, Fengdan;Lichenstein, Sarah D.;Yip, Sarah W.
女性更容易受到内在化障碍的影响（例如，抑郁和焦虑）。本研究采用综合发展的方法，调查多方面的因素与内在症状的性别差异的出现，使用的数据从青少年大脑认知发展（ABCD）的研究。性激素水平（脱氢表雄酮，睾酮和雌二醇），身体青春期发育，基于任务的功能性大脑活动，家庭冲突和内化症状的指标来自ABCD研究的基线样本（9- 10岁; N = 11，844）。主成分分析作为一种数据驱动的降维技术的内化分量表产生一个单一的强大的措施内化症状。适度的中介分析评估了已知的风险因素和内化症状之间的关联是否因性别而异。结果显示，身体青春期发育的内化症状，通过跨性别的家庭冲突的直接和间接影响。没有发现性激素水平或杏仁核对恐惧面孔的反应对内化症状的影响。女性没有报告整体更大的内化症状相对于男性，这表明内化症状尚未开始增加女性在这个年龄。研究结果提供了一个重要的基线，为未来的纵向研究内分泌，神经认知和心理社会因素与性别差异的内在症状。青春期是一个剧烈变化的时期，与精神病理学的发病有关。研究了9-10岁时内化症状的性别差异。内分泌，神经认知和心理社会因素之间的关联进行了测试。女性没有报告整体更大的内化症状相对于男性。结果提供了一个基线，为未来的纵向评估整个青春期。
Women are more vulnerable to internalizing disorders (e.g., depression and anxiety). This study took an integrative developmental approach to investigate multidimensional factors associated with the emergence of sex differences in internalizing symptoms, using data from the Adolescent Brain Cognitive Development (ABCD) study. Indices of sex hormone levels (dehydroepiandrosterone, testosterone, and estradiol), physical pubertal development, task-based functional brain activity, family conflict, and internalizing symptoms were drawn from the ABCD study’s baseline sample (9- to 10-year-old; N = 11,844). Principal component analysis served as a data-driven dimensionality reduction technique on the internalizing subscales to yield a single robust measure of internalizing symptoms. Moderated mediation analyses assessed whether associations between known risk factors and internalizing symptoms vary by sex. Results revealed direct and indirect effects of physical pubertal development on internalizing symptoms through family conflict across sexes. No effects were found of sex hormone levels or amygdala response to fearful faces on internalizing symptoms. Females did not report overall greater internalizing symptoms relative to males, suggesting that internalizing symptoms have not yet begun to increase in females at this age. Findings provide an essential baseline for future longitudinal research on the endocrine, neurocognitive, and psychosocial factors associated with sex differences in internalizing symptoms. Puberty is a time of drastic change associated with the onset of psychopathology. The emergence of sex differences in internalizing symptoms at ages 9–10 was studied. Associations between endocrine, neurocognitive and psychosocial factors were tested. Females did not report overall greater internalizing symptoms relative to males. Results provide a baseline for future longitudinal assessment across adolescence.
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影响因子：
64.5
作者：
Boyle EA;Li YI;Pritchard JK
通讯作者：
Pritchard JK
影响因子：
3
作者：
CURETON, EE
通讯作者：
CURETON, EE
影响因子：
2.1
作者：
Compian, Laura J.;Gowen, L. Kris;Hayward, Chris
通讯作者：
Hayward, Chris
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
影响因子：
6.6
作者：
Casey, B. J.;Getz, Sarah;Galvan, Adriana
通讯作者：
Galvan, Adriana