Beneficial effect of traditional chinese medicinal formula danggui-shaoyao-san on advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats.
Beneficial effect of traditional chinese medicinal formula danggui-shaoyao-san on advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats.
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DOI：
10.1155/2012/140103
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Chang CJ
中科院分区：
文献类型：
--
作者：
Liu IM;Tzeng TF;Liou SS;Chang CJ
本研究旨在探讨当归少药散（DSS）对糖尿病肾病的治疗作用。当归少药散是一种由6种中草药组成的著名中药配方。链脲佐菌素诱导的糖尿病大鼠连续12周口服DSS （2.8 g kg - 1 /天）。DSS能部分降低糖尿病大鼠的高血糖水平。在DSS治疗12周后，尿白蛋白、24小时尿白蛋白排泄率、肌酐清除率以及肾脏肥大（肾重/体重比）和肾小球系膜基质扩张的糖尿病依赖性改变得到改善。DSS对糖尿病大鼠肾脏核因子-κB、转化生长因子-β 1的表达升高和IV型胶原的逐渐积累也有一定的抑制作用。DSS不仅可以改善糖尿病大鼠肾脏中晚期糖基化终产物（AGEs）和N ε-（羧甲基）赖氨酸水平的升高，还可以改善肾脏中脂质过氧化产物的升高。DSS增强了糖尿病大鼠肾脏超氧化物二脲酶和谷胱甘肽过氧化物酶活性的降低。这些数据表明，DSS对stz -糖尿病大鼠的肾保护作用不仅可以通过调节血糖来减弱糖尿病肾小球中AGEs的表达，还可能反映了其抗氧化活性。
The present study was undertaken to characterize the effects of Danggui-Shaoyao-San (DSS), a famous traditional Chinese medicine formula consisting of six herbal medicines, on diabetic nephropathy. Streptozotocin-induced diabetic rats were orally administrated DSS (2.8 g kg−1 per day) for 12 consecutive weeks. DSS partially decreased the high plasma glucose level in diabetic rats. Diabetic-dependent alterations in urinary albumin, 24-hour urinary albumin excretion rate, and creatinine clearance as well as the kidney hypertrophy (kidney weight/body weight ratio) and glomerular mesangial matrix expansion were ameliorated after 12 weeks of DSS treatment. The increased expression of nuclear factor-κB as well as transforming growth factor-β 1 and the progressive accumulation of type IV collagen in kidney of diabetic rats were also attenuated by DSS. Not only the elevated levels of advanced glycation end products (AGEs) and N ε-(carboxymethyl)lysine but also the higher levels of lipid peroxidation products in kidney of diabetic rats were ameliorated by DSS. Decreased activity of superoxide diamutase and glutathione peroxidase in kidney of diabetic rats was enhanced by DSS. These data demonstrated that the renoprotective effects of DSS in STZ-diabetic rats not only were attributable to regulate plasma glucose to attenuate AGEs expression in diabetic glomeruli but also likely reflected its antioxidant activity.
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DOI：
10.1016/s0015-6264(67)83153-5
发表时间：
1967-01-01
期刊：
FOOD COSMET TOXICOL
影响因子：
--
作者：
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通讯作者：
MAYNARD, E. A.
影响因子：
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作者：
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DOI：
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发表时间：
2009-09-08
影响因子：
3.4
作者：
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通讯作者：
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影响因子：
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作者：
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