Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students.
Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students.
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脂质组学分析揭示了超重或肥胖青少年学生血浆脂质成分的明显差异。
DOI：
10.1186/s12902-021-00859-7
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发表时间：
2021-10-13
影响因子：
2.7
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Yin R;Wang X;Li K;Yu K;Yang L
血脂异常与肥胖之间的关系已被广泛报道，但与肥胖发展相关的全球血脂谱仍需澄清。对血脂谱与青少年肥胖之间关系的研究可能为肥胖的发展提供新的见解。采用质谱-液相色谱法检测了90名中国青少年空腹血浆总脂质组，其中肥胖青少年34名，超重青少年26名，体重指数正常青少年30名。所有参与者都使用InBody进行了人体测量。采用Cobas Elecsys生化分析仪测定临床生化指标。定性和定量分析均显示肥胖学生的血脂特征呈渐进性变化，表现出与超重学生接近的特点，但与正常学生有显著差异。与正常和超重学生相比，肥胖组甘油三酯（TG）、18-羟基皮质醇（18-hydroxycortisol）、异蛇麻酮A（isohumulinone A）和11-dihydro-12-norneoquassin水平上调，而磷脂酰胆碱（PC）、磷脂酰乙醇胺（PE）、lysoPC（LPC）、lysoPE（LPE）和磷脂酰肌醇（PI）水平下调。然后，我们进行了维恩图，并从3个配对比较中选择了8个重要的代谢产物。大多数选定的功能显着相关的人体测量。这项研究证明了八种重要代谢物与肥胖青少年之间的关系。这些脂质特征可能为评估肥胖风险和监测肥胖发展提供依据。在线版本包含补充材料，可通过10.1186/s12902-021-00859-7获得。
The relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity still need to be clarified. An investigation into the association between the lipidomic plasma profile and adolescent obesity may provide new insights into the development of obesity. Mass spectrometry coupled with liquid chromatography was applied to detect the global lipidome in the fasting plasma from 90 Chinese adolescents, including 34 obese adolescents, 26 overweight adolescents, and 30 adolescents with a normal body mass index (BMI). All participants underwent anthropometric measurements by using InBody. Clinical biochemical indicators were measured by Cobas Elecsys. Both qualitative and quantitative analyses revealed a gradual change in plasma lipid features among obese students, exhibiting characteristics close to overweight students, but differing significantly from normal students. Compared with normal and overweight students, levels of triglyceride (TG), 18-hydroxycortisol, isohumulinone A, and 11-dihydro-12-norneoquassin were up-regulated in the obese group, while phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysoPC (LPC), lysoPE (LPE), and phosphatidylinositol (PI) were significantly down-regulated in the obese group. Then, we conducted Venn diagrams and selected 8 significant metabolites from the 3 paired comparisons. Most of the selected features were significantly correlated with the anthropometric measurements. This study demonstrated evidence for a relationship between the eight significant metabolites with obese adolescents. These lipid features may provide a basis for evaluating risk and monitoring the development of obesity. The online version contains supplementary material available at 10.1186/s12902-021-00859-7.
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影响因子：
4.1
作者：
Köfeler HC;Fauland A;Rechberger GN;Trötzmüller M
通讯作者：
Trötzmüller M
影响因子：
3
作者：
Wen B;Mei Z;Zeng C;Liu S
通讯作者：
Liu S
影响因子：
3.4
作者：
Calling, Susanna;Hedblad, Bo;Janzon, Lars
通讯作者：
Janzon, Lars
影响因子：
5
作者：
Shabrina, A.;Tung, T. -H.;Huang, S. -Y.
通讯作者：
Huang, S. -Y.
影响因子：
5.5
作者：
Pikó P;Pál L;Szűcs S;Kósa Z;Sándor J;Ádány R
通讯作者：
Ádány R