A causal link between prediction errors, dopamine neurons and learning.
A causal link between prediction errors, dopamine neurons and learning.
复制标题
DOI：
10.1038/nn.3413
复制
发表时间：
2013-07
影响因子：
25
通讯作者：
Janak, Patricia H.
中科院分区：
文献类型：
--
作者：
Steinberg, Elizabeth E.;Keiflin, Ronald;Boivin, Josiah R.;Witten, Ilana B.;Deisseroth, Karl;Janak, Patricia H.
意外获得或拒绝奖励的情况代表了新学习的机会。通常，这种学习包括识别预测奖励可用性的线索。意想不到的奖励会强烈激活中脑多巴胺神经元。这种阶段性信号旨在通过发出实际结果与预期结果之间的差异（称为奖励预测误差）来支持对先行线索的学习。然而，尚不清楚多巴胺神经元预测错误信号和提示奖励学习是否存在因果关系。为了检验这一假设，我们通过两种行为程序（联想阻断和消退）操纵大鼠的多巴胺神经元活动，这说明了预测错误在学习中的基本功能。我们观察到，多巴胺神经元的光遗传学激活与奖励传递同时发生，模拟预测错误，足以导致线索引发的奖励寻求行为的持久增加。我们的研究结果确立了时间精确的多巴胺神经元信号在提示奖励学习中的因果作用，弥合了实验证据和有影响力的理论框架之间的关键差距。
Situations where rewards are unexpectedly obtained or withheld represent opportunities for new learning. Often, this learning includes identifying cues that predict reward availability. Unexpected rewards strongly activate midbrain dopamine neurons. This phasic signal is proposed to support learning about antecedent cues by signaling discrepancies between actual and expected outcomes, termed a reward prediction error. However, it is unknown whether dopamine neuron prediction error signaling and cue-reward learning are causally linked. To test this hypothesis, we manipulated dopamine neuron activity in rats in two behavioral procedures, associative blocking and extinction, that illustrate the essential function of prediction errors in learning. We observed that optogenetic activation of dopamine neurons concurrent with reward delivery, mimicking a prediction error, was sufficient to cause long-lasting increases in cue-elicited reward-seeking behavior. Our findings establish a causal role for temporally-precise dopamine neuron signaling in cue-reward learning, bridging a critical gap between experimental evidence and influential theoretical frameworks.
登录
查看更多内容
神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K
影响因子：
64.8
作者：
Burke, Kathryn A.;Franz, Theresa M.;Schoenbaum, Geoffrey
通讯作者：
Schoenbaum, Geoffrey