Comparing Mouse and Rat Hippocampal Place Cell Activities and Firing Sequences in the Same Environments.
Comparing Mouse and Rat Hippocampal Place Cell Activities and Firing Sequences in the Same Environments.
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DOI：
10.3389/fncel.2018.00332
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发表时间：
2018
影响因子：
5.3
通讯作者：
Ji D
中科院分区：
文献类型：
--
作者：
Mou X;Cheng J;Yu YSW;Kee SE;Ji D
海马位置细胞是空间表征和空间记忆加工的关键。它们在空间中的特定位置（位置场）开火，并在θ序列和与涟漪相关的重放事件中以精确的模式开火。这些现象在大鼠中得到了广泛的研究，但在小鼠中的研究程度较低。通用的遗传操作的可用性使小鼠在定位细胞研究中具有优势。然而，目前还不清楚在相同的环境中，小鼠和大鼠之间的位置场和位置细胞序列有何不同。在这里，我们提供了一个定量的比较，在现场的属性，以及θ序列和重放，大鼠和小鼠之间，因为他们跑在同一个新的轨道，因为他们休息后。我们发现，小鼠的位置细胞显示较少的空间特异性，更多但更小的位置场。小鼠的θ振荡、θ相位进动和θ序列的方面与大鼠相似。然而，在小鼠停在新轨道上时，与涟漪相关的重放相对罕见。在跑道跑步后的休息期间存在重放，但小鼠中的重放比大鼠中的重放弱。我们的研究结果表明，小鼠和大鼠的位置细胞在质量上是相似的，但有很大的数量差异。
Hippocampal place cells are key to spatial representation and spatial memory processing. They fire at specific locations in a space (place fields) and fire in precise patterns during theta sequences and during ripple-associated replay events. These phenomena have been extensively studied in rats, but to a less extent in mice. The availability of versatile genetic manipulations gives mice an advantage for place cell studies. However, it is unknown how place fields and place cell sequences in the same environment differ between mice and rats. Here, we provide a quantitative comparison in place field properties, as well as theta sequences and replays, between rats and mice as they ran on the same novel track and as they rested afterwards. We found that place cells in mice display less spatial specificity with more but smaller place fields. Theta oscillations, theta phase precession and aspects of theta sequences in mice are similar as those in rats. The ripple-associated replay, however, is relatively rare during stopping on the novel track in mice. The replay is present during resting after the track running, but is weaker in mice than the replay in rats. Our results suggest that place cells in mice and rats are qualitatively similar, but with substantial quantitative differences.
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