Pattern formation today.
Pattern formation today.
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DOI：
10.1387/ijdb.082594cc
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Richardson MK
中科院分区：
文献类型：
--
作者：
Chuong CM;Richardson MK
模式是嵌入随机性中的顺序。它们可能以空间排列或时间序列的形式出现，要素可能相同或有变化。模式既存在于物理世界中，也存在于生命系统中。在生物世界中，模式可以从简单到复杂，形成生命的基本组成部分。在生物世界中产生这种秩序的过程被称为模式形成。自四十年前Wolpert提出这一概念以来，分子生物学、发育生物学、干细胞生物学、组织工程、理论建模等学科的科学家在了解其机制方面取得了显着进展。现在是审查和重新整合我们的理解的时候了。在这里，我们将探索模式形成的起源，遗传密码如何被翻译成生物形式，以及复杂的表型如何在进化过程中被选择。我们提出了四个主题：原则，进化，发展，干细胞和再生。我们采访了该领域的几位领导者，以深入了解他们的研究和模式形成领域如何相互塑造。我们已经了解到，分子过程和物理化学原理对生物模式的形成都很重要。通过整合分子遗传操作的分析方法和模型模拟的系统方法，将出现新的理解。我们很遗憾，我们不能包括在该领域的每一个主要的研究人员，但希望这一特别问题的国际J。代表了我们今天对模式形成的知识的一个样本，这将有助于激发对这一基本过程的更多研究。
Patterns are orders embedded in randomness. They may appear as spatial arrangements or temporal series, and the elements may appear identical or with variations. Patterns exist in the physical world as well as in living systems. In the biological world, patterns can range from simple to complex, forming the basic building blocks of life. The process which generates this ordering in the biological world was termed pattern formation. Since Wolpert promoted this concept four decades ago, scientists from molecular biology, developmental biology, stem cell biology, tissue engineering, theoretical modeling and other disciplines have made remarkable progress towards understanding its mechanisms. It is time to review and re-integrate our understanding. Here, we explore the origin of pattern formation, how the genetic code is translated into biological form, and how complex phenotypes are selected over evolutionary time. We present four topics: Principles, Evolution, Development, and Stem Cells and Regeneration. We have interviewed several leaders in the field to gain insight into how their research and the field of pattern formation have shaped each other. We have learned that both molecular process and physico-chemical principles are important for biological pattern formation. New understanding will emerge through integration of the analytical approach of molecular-genetic manipulation and the systemic approach of model simulation. We regret that we could not include every major investigator in the field, but hope that this Special Issue of the Int. J. Dev. Biol. represents a sample of our knowledge of pattern formation today, which will help to stimulate more research on this fundamental process.
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DOI：
10.1387/ijdb.072556cc
发表时间：
2009
期刊：
The International journal of developmental biology
影响因子：
--
作者：
Chang C;Wu P;Baker RE;Maini PK;Alibardi L;Chuong CM
通讯作者：
Chuong CM
DOI：
10.1387/ijdb.072493rb
发表时间：
2009
期刊：
The International journal of developmental biology
影响因子：
--
作者：
Baker RE;Schnell S;Maini PK
通讯作者：
Maini PK
影响因子：
0.7
作者：
Plikus, Maksim V.;Widelitz, Randall B.;Chuong, Cheng-Ming
通讯作者：
Chuong, Cheng-Ming
影响因子：
56.9
作者：
Dequeant, Mary-Lee;Glynn, Earl;Pourquie, Olivier
通讯作者：
Pourquie, Olivier
影响因子：
0.7
作者：
Peter, Isabelle S.;Davidson, Eric H.
通讯作者：
Davidson, Eric H.