The "Task B problem" and other considerations in developmental functional neuroimaging.

The "Task B problem" and other considerations in developmental functional neuroimaging.
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DOI:
10.1002/hbm.21036
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发表时间:
2010-06
影响因子:
4.8
通讯作者:
Schlaggar, Bradley L.
Schlaggar, Bradley L.
中科院分区:
医学2区
文献类型:
--
作者:
Church, Jessica A.;Petersen, Steven E.;Schlaggar, Bradley L.

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功能神经成像提供了一种非凡的工具,使我们能够以安全的方式研究不同年龄段和特殊人群的认知。然而,实验者面临着许多方法论问题,这些问题在为儿童成像时尤其相关。这篇简短的文章讨论了评估任务绩效,处理群体绩效差异的策略,运动控制,统计能力,适当的图谱注册,以及数据分析策略。此外,还将讨论对解释fMRI数据具有重要意义的另外两个主题:成人和儿童之间的功能神经解剖学差异是否是假定的发育神经血管差异的结果,以及解释负的血氧水平依赖(BOLD)信号变化的问题。
Functional neuroimaging provides a remarkable tool to allow us to study cognition across the lifespan and in special populations in a safe way. However, experimenters face a number of methodological issues, and these issues are particularly pertinent when imaging children. This brief article discusses assessing task performance, strategies for dealing with group performance differences, controlling for movement, statistical power, proper atlas registration, and data analysis strategies. In addition, there will be discussion of two other topics that have important implications for interpreting fMRI data: the question of whether functional neuroanatomical differences between adults and children are the consequence of putative developmental neurovascular differences, and the issue of interpreting negative blood oxygenation-level dependent (BOLD) signal change.
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