Dopamine D1 receptor number — a sensitive PET marker for early brain degeneration in Huntington's disease
Dopamine D1 receptor number — a sensitive PET marker for early brain degeneration in Huntington's disease
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多巴胺 D1 受体数量——亨廷顿病早期脑部退化的敏感 PET 标记
DOI：
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发表时间：
2005
影响因子：
4.7
通讯作者：
L. Farde
中科院分区：
文献类型：
--
作者：
G. Sedvall;P. Karlsson;A. Lundin;M. Anvret;T. Suhara;C. Halldin;L. Farde
摘要 通过正电子发射断层扫描 (PET) 测定了五名亨廷顿病患者、一名无症状基因携带者和五名对照受试者的大脑中 D1-多巴胺受体结合情况。 [11C]SCH 23390用作放射性配体。通过 MRI 记录大脑形态。与对照组相比，所有患有轻度至中度功能障碍的患者的壳核体积和 D1-多巴胺受体密度均减少了近 50%。患者组壳核中 D1-多巴胺受体总数减少了 75%。尾状核也发现了类似的减少。无症状基因携带者的体积和密度值处于对照受试者的较低范围内。在有症状的患者中，额叶新皮质中的 D1-多巴胺受体结合也趋于减少。结果表明，[11C]SCH 23390 结合与 MRI 结合可用作亨廷顿病早期脑变性的敏感标记。该标记可用于监测疾病基因的病理生理学效应，也可用于跟踪旨在预防退行性过程的治疗干预。
SummaryD1-dopamine receptor binding in the brain was determined by positron emission tomography (PET) in five patients with Huntington's disease, in one asymptomatic gene carrier and in five control subjects. [11C] SCH 23390 was used as the radioligand. Brain morphology was recorded by MRI. The patients who all had a mild to moderate functional impairment showed an almost 50% reduction of putamen volume as well as D1-dopamine receptor density as compared to the controls. The total D1-dopamine receptor number in the putamen was reduced by 75% in the patient group. A similar reduction was found for the caudate nucleus. The asymptomatic gene carrier had volume and density values in the lower range of the control subjects. In the frontal neocortex there also tended to be a reduced D1-dopamine receptor binding in the symptomatic patients. The results indicate that [11C] SCH 23390 binding in combination with MRI can be used as a sensitive marker for early brain degeneration in Huntington's disease. This marker may be useful to monitor the pathophysiological effect of the disease gene and also to follow therapeutic interventions aiming at preventing the degenerative process.
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影响因子：
56.9
作者：
GRAVELAND, GA;WILLIAMS, RS;DIFIGLIA, M
通讯作者：
DIFIGLIA, M
异常运动的测量：针对亨廷顿病开发的方法。
DOI：
--
发表时间：
1983
期刊：
Neurobehavioral toxicology and teratology
影响因子：
--
作者：
Folstein,SE;Jensen,B;Leigh,RJ;Folstein,MF
通讯作者：
Folstein,MF
DOI：
10.1056/nejm198611133152006
发表时间：
1986-11
期刊：
The New England journal of medicine
影响因子：
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作者：
J. B. Martin;J. Gusella
通讯作者：
J. B. Martin;J. Gusella
DOI：
--
发表时间：
1991-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
J. Meador-Woodruff;A. Mansour;Daniel J. Healy;Rebekah Kuehn;Qun-Yong Zhou;J. Bunzow;Huda Akil;Olivier Civelli;Stanley J. Watson
通讯作者：
J. Meador-Woodruff;A. Mansour;Daniel J. Healy;Rebekah Kuehn;Qun-Yong Zhou;J. Bunzow;Huda Akil;Olivier Civelli;Stanley J. Watson
亨廷顿病中的 D2 受体：正电子发射断层扫描结果和临床相关性。
DOI：
10.1176/jnp.2.1.20
发表时间：
1990
期刊：
The Journal of neuropsychiatry and clinical neurosciences
影响因子：
--
作者：
Brandt,J;Folstein,SE;Wong,DF;Links,J;Dannals,RF;McDonnell-Sill,A;Starkstein,S;Anders,P;Strauss,ME;Tune,LE
通讯作者：
Tune,LE