Utilizing a unique animal model to better understand human temperament.
Utilizing a unique animal model to better understand human temperament.
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DOI:
10.1016/j.cobeha.2017.02.002
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发表时间:
2017-04
影响因子:
5
通讯作者:
Akil H
中科院分区:
文献类型:
--
作者:
Turner CA;Flagel SB;Blandino P Jr;Watson SJ Jr;Akil H
Individual differences in temperament are associated with psychopathology in humans. Moreover, the relationship between temperament and anxiety-, depression-, PTSD- and addiction-related behaviors can be modeled in animals. This review will highlight these relationships with a focus on individual differences in the response to stressors, fear conditioning and drugs of abuse using animals that differ in their response to a novel environment. We will discuss behavioral and neurobiological commonalities amongst these behaviors with a focus on the hippocampus and, in particular, growth factors as promising novel targets for therapeutic intervention.
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