The Associations of Chronotype and Shift Work With Rheumatoid Arthritis.
The Associations of Chronotype and Shift Work With Rheumatoid Arthritis.
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DOI：
10.1177/07487304231179595
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发表时间：
2023-10
影响因子：
3.5
通讯作者：
Gibbs, Julie E.
中科院分区：
文献类型：
--
作者：
Butler, Thomas D.;Maidstone, Robert J.;Rutter, Martin K.;McLaughlin, John T.;Ray, David W.;Gibbs, Julie E.
生物钟调节人类生理的多个方面，包括免疫。人们有一种被称为时型的昼夜节律偏好。喜欢晚上工作的人可能更适合倒班工作，但也有更高的健康不良风险。倒班工作会导致昼夜节律失调，并与哮喘和癌症等炎症性疾病的风险增加有关。在这里，我们调查了时型、倒班工作和类风湿性关节炎(RA)之间的关系。在多达444,210名英国生物库参与者中，研究了轮班工作暴露和时型对类风湿关节炎风险的相关性。调整多因素Logistic回归模型的协变量：年龄、性别、种族、饮酒、吸烟史、汤森剥夺指数(TDI)、睡眠时间、工作周长度和体重指数(BMI)。在调整协变量后，与中等时型相比，晨型个体患类风湿性关节炎(RA；优势比[OR]：0.93，95%可信区间[CI]：0.88-0.99)的几率较低。清晨时型与类风湿性关节炎之间的关联持续存在更严格的类风湿性关节炎病例定义(协变量调整后的OR：0.89，95%CI：0.81-0.97)。在调整了年龄、性别、种族和TDI后，与进一步调整协变量后减弱为零的日班工人相比，倒班工人患RA的几率(OR：1.22，95%CI：1.1-1.36)更高(OR：1.1，95%CI：0.98-1.22)。晨间固定夜班工作的时型比白天工作的人患类风湿性关节炎的几率高(OR：1.89，95%CI：1.19~2.99)。这些数据表明昼夜节律在类风湿关节炎发病机制中的作用。需要进一步的研究来确定这种联系的潜在机制，并了解倒班工作对慢性炎症性疾病及其中介因素的潜在影响。
The circadian clock regulates multiple aspects of human physiology including immunity. People have a circadian preference termed chronotype. Those with an evening preference may be better suited to shift work, but also carry higher risk of adverse health. Shift work leads to misalignment of circadian rhythms and is associated with increased risk of inflammatory disease such as asthma and cancer. Here, we investigate the association between chronotype, shift work, and rheumatoid arthritis (RA). The associations between exposures of shift work and chronotype on risk of RA were studied in up to 444,210 U.K. Biobank participants. Multivariable logistic regression models were adjusted for covariates: age, sex, ethnicity, alcohol intake, smoking history, Townsend Deprivation Index (TDI), sleep duration, length of working week, and body mass index (BMI). After adjusting for covariates, individuals with a morning chronotype had lower odds of having rheumatoid arthritis (RA; odds ratio [OR]: 0.93, 95% confidence interval [CI]: 0.88-0.99) when compared to intermediate chronotypes. The association between morning chronotype and RA persisted with a more stringent RA case definition (covariate-adjusted OR: 0.89, 95% CI: 0.81-0.97). When adjusted for age, sex, ethnicity, and TDI, shift workers had higher odds of RA (OR: 1.22, 95% CI: 1.1-1.36) compared to day workers that attenuated to the null after further covariate adjustment (OR: 1.1, 95% CI: 0.98-1.22). Morning chronotypes working permanent night shifts had significantly higher odds of RA compared to day workers (OR: 1.89, 95% CI: 1.19-2.99). These data point to a role for circadian rhythms in RA pathogenesis. Further studies are required to determine the mechanisms underlying this association and understand the potential impact of shift work on chronic inflammatory disease and its mediating factors.
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影响因子：
4.9
作者：
Gibbs JE;Ray DW
通讯作者：
Ray DW
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
10
作者：
Maidstone R;Anderson SG;Ray DW;Rutter MK;Durrington HJ;Blaikley JF
通讯作者：
Blaikley JF
免疫介导的炎症性疾病患者的表型：系统评价。
影响因子：
3.5
作者：
Butler, Thomas D.;Ali, Aala Mohammed;Gibbs, Julie E.;McLaughlin, John T.
通讯作者：
McLaughlin, John T.
影响因子：
50
作者：
Foster, Hatnish M. E.;Celis-Morales, Carlos A.;Mair, Frances S.
通讯作者：
Mair, Frances S.