Functional mapping of the neural circuitry of rat maternal motivation: effects of site-specific transient neural inactivation.
Functional mapping of the neural circuitry of rat maternal motivation: effects of site-specific transient neural inactivation.
复制标题
大鼠母性动机神经回路的功能图谱：位点特异性短暂神经失活的影响。
DOI：
10.1111/j.1365-2826.2011.02200.x
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发表时间：
2011-11
影响因子：
3.2
通讯作者：
Morrell JI
中科院分区：
文献类型：
--
作者：
Pereira M;Morrell JI
本综述重点关注我们实验室的最新研究，这些研究检查了产后大鼠母亲动机的神经回路。我们采用了一种通过输注布比卡因的位点特异性神经失活方法，使用两种互补的行为方法来绘制母体动机回路：无条件的母体反应和在并发的幼犬/可卡因选择条件位置偏好任务中选择幼犬而非可卡因条件激励。我们的研究结果表明，在产后早期，不同的大脑结构，包括内侧视前区、腹侧被盖区和内侧前额皮质下边缘和前扣带回亚区，对激励回路产生了幼犬特异性的偏见。随着产后期的进展和幼崽逐渐长大，我们的研究结果进一步表明，母体反应性逐渐减少对内侧视前区和内侧前额叶皮层下边缘活动的依赖，而更多地分布在母体回路中，这样额外的网络组件，包括内侧前额叶皮层前边缘亚区域，会随着母体经验而被招募，并有助于产后晚期母体行为的表达。总的来说，我们的研究结果提供了强有力的证据，表明产后雌性成功照顾发育中婴儿的卓越能力受到分布式神经网络的促进，该网络对复杂的、不断变化的传入环境和幼崽相关的刺激进行有效和动态的处理，最终允许在产后期间适当表达的进展和母亲反应性的减弱。
The present review focuses on recent studies from our laboratory examining the neural circuitry subserving rat maternal motivation across postpartum. We employed a site-specific neural inactivation method by infusion of bupivacaine to map the maternal motivation circuitry using two complementary behavioral approaches: unconditioned maternal responsiveness and choice of pup- over cocaine-conditioned incentives in a concurrent pup/cocaine choice conditioned place preference task. Our findings revealed that during the early postpartum period, distinct brain structures, including the medial preoptic area, ventral tegmental area and medial prefrontal cortex infralimbic and anterior cingulate subregions, contribute a pup-specific bias to the motivational circuitry. As the postpartum period progresses and the pups grow older, our findings further revealed that maternal responsiveness becomes progressively less dependent on medial preoptic area and medial prefrontal cortex infralimbic activity, and more distributed in the maternal circuitry, such that additional network components, including the medial prefrontal cortex prelimbic subregion, are recruited with maternal experience, and contribute to the expression of late postpartum maternal behavior. Collectively, our findings provide strong evidence that the remarkable ability of postpartum females to successfully care for their developing infants is subserved by a distributed neural network that carries out efficient and dynamic processing of complex, constantly changing incoming environmental and pup-related stimuli, ultimately allowing the progression of appropriate expression and waning of maternal responsiveness across the postpartum period.
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影响因子：
3.4
作者：
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