Ultra-widefield color fundus photography combined with high-speed ultra-widefield swept-source optical coherence tomography angiography for non-invasive detection of lesions in diabetic retinopathy.
Ultra-widefield color fundus photography combined with high-speed ultra-widefield swept-source optical coherence tomography angiography for non-invasive detection of lesions in diabetic retinopathy.
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DOI：
10.3389/fpubh.2022.1047608
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发表时间：
2022
影响因子：
5.2
通讯作者：
Zhong, Jie
中科院分区：
文献类型：
--
作者：
Li, Jie;Wei, Dingyang;Mao, Mingzhu;Li, Mengyu;Liu, Sanmei;Li, Fang;Chen, Li;Liu, Miao;Leng, Hongmei;Wang, Yiya;Ning, Xinru;Liu, Yi;Dong, Wentao;Zhong, Jie
关键词：
比较超宽视野彩色眼底照相（UWF CFP）联合高速超宽视野扫频光源光学相干断层血管造影（UWF SS-OCTA）或荧光素血管造影（FFA）对糖尿病视网膜病变（DR）的检出率及DR严重程度分级的一致性。这项前瞻性、观察性研究招募了2021年11月至2022年6月期间已经接受FFA检查的糖尿病患者。这些患者没有DR或DR的任何阶段。所有参与者使用24 × 20 mm扫描模型使用200 ° UWF CFP和UWF SS-OCTA成像。独立评价图像是否存在DR病变，包括微动脉瘤（MA）、视网膜内出血（IRH）、非灌注区（NPA）、视网膜内微血管异常（IRMA）、静脉串珠（VB）、其他部位新生血管（NVE）、视盘新生血管（NVD）和玻璃体或视网膜前出血（VH/PRH）。比较了基于UWF CFP + UWF SS-OCTA和UWF CFP + FFA的DR严重程度分级的一致性。所有统计分析均采用SPSS V.26.0进行。86名参与者的153只眼入组研究。UWF CFP联合UWF SS-OCTA对所有特征性DR病变的检出率与UWF CFP联合FFA相似（p> 0.05），但NPA除外（p = 0.039）。两种组合方法之间的VB识别结果显示出良好的一致性（κ = 0.635），其余DR病变的一致性非常好（κ值范围为0.858 - 0.974）。在比较DR严重程度分级时，UWF CFP + UWF SS-OCTA与UWF CFP + FFA之间达到了非常好的一致性（κ = 0.869）。UWF CFP + UWF SS-OCTA与UWF CFP + FFA相比，在检测DR病变和确定DR严重程度方面具有非常好的一致性。这种模式有可能被用作一种快速，可靠，非侵入性的方法，DR筛选和监测在未来。
To compare the detection rate of diabetic retinopathy (DR) lesions and the agreement of DR severity grading using the ultra-widefield color fundus photography (UWF CFP) combined with high-speed ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA) or fluorescein angiography (FFA). This prospective, observational study recruited diabetic patients who had already taken the FFA examination from November 2021 to June 2022. These patients had either no DR or any stage of DR. All participants were imaged with a 200° UWF CFP and UWF SS-OCTA using a 24 × 20 mm scan model. Images were independently evaluated for the presence or absence of DR lesions including microaneurysms (MAs), intraretinal hemorrhage (IRH), non-perfusion areas (NPAs), intraretinal microvascular abnormalities (IRMAs), venous beading (VB), neovascularization elsewhere (NVE), neovascularization of the optic disc (NVD), and vitreous or preretinal hemorrhage (VH/PRH). Agreement of DR severity grading based on UWF CFP plus UWF SS-OCTA and UWF CFP plus FFA was compared. All statistical analyses were performed using SPSS V.26.0. One hundred and fifty-three eyes of 86 participants were enrolled in the study. The combination of UWF CFP with UWF SS-OCTA showed a similar detection rate compared with UWF CFP plus FFA for all the characteristic DR lesions (p>0.05), except NPAs (p = 0.039). Good agreement was shown for the identification of VB (κ = 0.635), and very good agreement for rest of the DR lesions between the two combination methods (κ-value ranged from 0.858 to 0.974). When comparing the grading of DR severity, very good agreement was achieved between UWF CFP plus UWF SS-OCTA and UWF CFP plusr FFA (κ = 0.869). UWF CFP plus UWF SS-OCTA had a very good agreement in detecting DR lesions and determining the severity of DR compared with UWF CFP plus FFA. This modality has the potential to be used as a fast, reliable, and non-invasive method for DR screening and monitoring in the future.
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影响因子：
13.7
作者：
Olsen, Timothy W.;Al-Rajhi, Ali;Lum, Flora C.
通讯作者：
Lum, Flora C.
影响因子：
2.7
作者：
Xuan, Yi;Chang, Qing;Wang, Min
通讯作者：
Wang, Min
影响因子：
3.9
作者：
Ashraf M;Cavallerano JD;Sun JK;Silva PS;Aiello LP
通讯作者：
Aiello LP
影响因子：
16.2
作者：
Solomon SD;Chew E;Duh EJ;Sobrin L;Sun JK;VanderBeek BL;Wykoff CC;Gardner TW
通讯作者：
Gardner TW
影响因子：
3.2
作者：
Ofuji, Yoshiko;Katada, Yusaku;Tomita, Yohei;Nagai, Norihiro;Sonobe, Hideki;Watanabe, Kazuhiro;Shinoda, Hajime;Ozawa, Yoko;Negishi, Kazuno;Tsubota, Kazuo;Kurihara, Toshihide
通讯作者：
Kurihara, Toshihide