Signals and mechanics shaping compartment boundaries in Drosophila
Signals and mechanics shaping compartment boundaries in Drosophila
复制标题
塑造果蝇区室边界的信号和机制
DOI：
10.1002/wdev.178
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Dahmann
中科院分区：
文献类型：
--
作者：
Umetsu;Dahmann
在动物的发育过程中，具有相似命运和功能的细胞群经常聚集在一起，并与具有不同命运的细胞分开。这种细胞行为的一个例子是隔室的形成，即具有相似命运的细胞群，它们与相邻的细胞群被清晰的边界分开。combustion通过作为生长和基因表达的单位在图案形成过程中发挥重要作用。隔室之间的边界与分泌指示整个组织生长和分化的信号分子的组织者有关。隔室之间的边界的直线形状对于保持组织器的位置和形状并且因此对于精确图案化是重要的。然而，室边界的直线形状受到许多发育组织中发生的细胞分裂和细胞插入的挑战。早期的工作确立了选择基因和信号通路在建立和保持边界直线方面的作用。最近在果蝇中的工作已经开始进一步揭示维持区室边界的物理和细胞机制。隔室分离的关键是沿边界沿着细胞连接处的肌动球蛋白依赖性机械张力的局部增加。增加的机械张力作为细胞分裂期间细胞混合的屏障，并以保持边界的直线形状的方式影响细胞沿沿着隔室边界插入期间的细胞重排。未来的一个重要问题是维持区室边界的直线形状的信号传导途径如何控制沿这些边界的沿着机械张力.WIRES Dev Biol 2015，4：407-417. doi：10.1002/wdev.178这篇文章分类下：建立空间和时间模式>细胞分选和边界形成
During animal development groups of cells with similar fates and functions often stay together and separate from cells with different fates. An example for this cellular behavior is the formation of compartments, groups of cells with similar fates that are separated by sharp boundaries from neighboring groups of cells. Compartments play important roles during patterning by serving as units of growth and gene expression. Boundaries between compartments are associated with organizers that secrete signaling molecules instructing growth and differentiation throughout the tissue. The straight shape of the boundary between compartments is important for maintaining the position and shape of the organizer and thus for precise patterning. The straight shape of compartment boundaries, however, is challenged by cell divisions and cell intercalations that take place in many developing tissues. Early work established a role for selector genes and signaling pathways in setting up and keeping boundaries straight. Recent work inDrosophilahas now begun to further unravel the physical and cellular mechanisms that maintain compartment boundaries. Key to the separation of compartments is a local increase of actomyosin‐dependent mechanical tension at cell junctions along the boundary. Increased mechanical tension acts as a barrier to cell mixing during cell division and influences cell rearrangements during cell intercalations along the compartment boundary in a way that the straight shape of the boundary is maintained. An important question for the future is how the signaling pathways that maintain the straight shape of compartment boundaries control mechanical tension along these boundaries.WIREs Dev Biol2015, 4:407–417. doi: 10.1002/wdev.178This article is categorized under:Establishment of Spatial and Temporal Patterns > Cell Sorting and Boundary Formation
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DOI：
10.1242/dev.124.20.4053
发表时间：
1997
期刊：
Development (Cambridge, England)
影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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DOI：
10.1242/dev.128.4.571
发表时间：
2001
期刊：
Development (Cambridge, England)
影响因子：
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影响因子：
9.2
作者：
Umetsu;Aigouy;Jülicher;Dahmann
通讯作者：
Dahmann
影响因子：
64.8
作者：
Micchelli, CA;Blair, SS
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