Fully 3D printed fluidic devices with integrated valves and pumps for flow injection analysis.
Fully 3D printed fluidic devices with integrated valves and pumps for flow injection analysis.
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DOI：
10.1039/d1ay01569a
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发表时间：
2021-11-04
期刊：
影响因子：
--
通讯作者：
Martin RS
中科院分区：
文献类型：
--
作者：
Castiaux AD;Selemani MA;Ward MA;Martin RS
描述了使用PolyJet 3D打印机创建集成阀门和泵的微流体装置。该工艺使用液体支撑和堆叠打印，产生完全打印的设备，经过最小的后处理后，在制造后几分钟内即可使用。PolyJet打印的一个独特功能是能够将几种不同性质的不同材料合并到一个打印中。在这项工作中，使用了两种商业上可用的材料：使用刚性透明塑料材料（VeroClear）来定义通道区域和设备的主体，而泵/阀则用柔性橡胶状材料（Agilus30）打印。整个过程，从最初的设计到测试需要不到4个小时完成。用荧光显微镜对阀和泵的性能进行了表征。该公司开发了一种流动注入分析设备，能够对分析物桥塞进行离散注入，并使用片上泵来移动流体流。发现注射过程可重复性好，且与分析物浓度变化呈线性相关。荧光标记内皮细胞的注射和快速裂解证明了这种效用。在一个过程中生产具有集成泵/阀的设备的能力显着增加了3D打印用于创建用于分析测量的微流体设备的适用性。描述了使用PolyJet 3D打印机创建集成阀门和泵的微流体装置。该公司开发了一种流动注入分析设备，能够对分析物桥塞进行离散注入，并使用片上泵来移动流体流。
The use of a PolyJet 3D printer to create a microfluidic device that has integrated valves and pumps is described. The process uses liquid support and stacked printing to result in fully printed devices that are ready to use within minutes of fabrication after minimal post-processing. A unique feature of PolyJet printing is the ability to incorporate several different materials of varying properties into one print. In this work, two commercially available materials were used: a rigid- transparent plastic material (VeroClear) was used to define the channel regions and the bulk of the device, while the pumps/valves were printed in a flexible, rubber-like material (Agilus30). The entire process, from initial design to testing takes less than 4 hours to complete. The performance of the valves and pumps were characterized by fluorescence microscopy. A flow injection analysis device that enabled the discrete injections of analyte plugs was created, with on-chip pumps being used to move the fluid streams. The injection process was found to be reproducible and linearly correlated with changes in analyte concentration. The utility was demonstrated with the injection and rapid lysis of fluorescently-labeled endothelial cells. The ability to produce a device with integrated pumps/valves in one process significantly adds to the applicability of 3D printing to create microfluidic devices for analytical measurements. The use of a PolyJet 3D printer to create a microfluidic device that has integrated valves and pumps is described. A flow injection analysis device that enabled the discrete injections of analyte plugs was created, with on-chip pumps being used to move the fluid streams.
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3D打印的微流体。
DOI：
10.1002/anie.201504382
发表时间：
2016-03-14
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Au AK;Huynh W;Horowitz LF;Folch A
通讯作者：
Folch A
影响因子：
4.4
作者：
Elinger, Dalia;Gabashvili, Alexandra;Levin, Yishai
通讯作者：
Levin, Yishai
影响因子：
7.4
作者：
Liu, J;Hansen, C;Quake, SR
通讯作者：
Quake, SR
影响因子：
19
作者：
Dixon, Christopher;Lamanna, Julian;Wheeler, Aaron R.
通讯作者：
Wheeler, Aaron R.
影响因子：
6.1
作者：
Lee YS;Bhattacharjee N;Folch A
通讯作者：
Folch A