3D-Printed Microfluidics.

3D-Printed Microfluidics.
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3D打印的微流体。

DOI:
10.1002/anie.201504382
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发表时间:
2016-03-14
期刊:
Angewandte Chemie (International ed. in English)
影响因子:
--
通讯作者:
Folch A
Folch A
中科院分区:
其他
文献类型:
--
作者:
Au AK;Huynh W;Horowitz LF;Folch A

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软光刻的出现使微流体领域得到了前所未有的扩展。然而,绝大多数PDMS微流体装置仍然是由大量的手工劳动制成的,被束缚在庞大的控制系统上,并且具有繁琐的用户界面,所有这些都使得商业化变得困难。另一方面,“3D打印革命”已经开始涵盖吸引微流体开发人员的尺寸和材料范围。在制造之前,设计以数字方式构建为详细的3D CAD文件。该设计可以通过远程协作团队组装成模块,并且可以使用有限元建模来模拟其机械和流体行为。由于结构是通过添加材料而不需要蚀刻或溶解来创建的,因此加工在环境和经济上都是有效的。我们预测,在未来几年内,3D打印将取代学术界的大多数PDMS和塑料成型技术。在这篇综述中,我们描述了与微流体设备制造相关的3D打印技术,并提供了使用每种技术构建的设备的示例。我们探讨了光固化快速成型的特点,这使得它成为一种很有前途的技术,以取代成型的原型和小规模制造。最后,我们确定了有前途的新技术和方向,这些技术和方向将继续推动3D打印微流体的边界。
The advent of soft lithography allowed for an unprecedented expansion in the field of microfluidics. However, the vast majority of PDMS microfluidic devices are still made with extensive manual labor, are tethered to bulky control systems, and have cumbersome user interfaces, all of which makes commercialization difficult. On the other hand, the “3D-printing revolution” has begun to embrace the range of sizes and materials that appeal to microfluidic developers. Prior to fabrication, a design is digitally built as a detailed 3D CAD file. The design can be assembled in modules by remotely collaborating teams, and its mechanical and fluidic behavior can be simulated using finite-element modeling. Because structures are created by adding materials without the need for etching or dissolution, processing is environmentally and economically efficient. We predict that in the next few years, 3D-printing will replace most PDMS and plastic molding techniques in academia. In this review, we describe the 3D-printing techniques relevant to the fabrication of microfluidic devices and provide examples of devices built using each technique. We explore the features of stereolithography which make it a promising technique to replace molding for prototyping and small-scale manufacturing. Finally, we identify promising new technologies and directions which will continue to push the boundaries of 3D-printed microfluidics.
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