ATRP in the design of functional materials for biomedical applications.

ATRP in the design of functional materials for biomedical applications.
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DOI:
10.1016/j.progpolymsci.2011.08.001
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发表时间:
2012-01-01
影响因子:
27.1
通讯作者:
Matyjaszewski K
Matyjaszewski K
中科院分区:
化学1区
文献类型:
--
作者:
Siegwart DJ;Oh JK;Matyjaszewski K

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原子转移自由基聚合(ATRP)是一种设计和制备多功能纳米结构材料的有效技术,可用于生物和医学领域的各种应用。ATRP能够精确控制大分子的结构,顺序和功能,这是新兴的生物医学设计的重要考虑因素。本文综述了ATRP在聚合物基纳米材料制备方面的最新进展,包括聚合物生物偶联物、嵌段共聚物基药物释放系统、交联微凝胶/纳米凝胶、诊断和成像平台、组织工程水凝胶以及可降解聚合物等。据设想,在分子水平上的精确工程将转化为定制的宏观物理性质,从而实现生物医学应用的关键要素的控制。
Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.
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期刊: MACROMOLECULES
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