Prenatal drug exposure to illicit drugs alters working memory-related brain activity and underlying network properties in adolescence.
Prenatal drug exposure to illicit drugs alters working memory-related brain activity and underlying network properties in adolescence.
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DOI：
10.1016/j.ntt.2015.02.002
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发表时间：
2015-03
影响因子：
2.9
通讯作者：
Salmeron BJ
中科院分区：
文献类型：
--
作者：
Schweitzer JB;Riggins T;Liang X;Gallen C;Kurup PK;Ross TJ;Black MM;Nair P;Salmeron BJ
产前药物暴露（PDE）对青春期大脑功能的持续影响知之甚少。我们探讨了神经激活的视觉空间工作记忆（VSWM）与控制任务使用功能磁共振成像（fMRI）在青少年PDE和社区对照组（CC）的非暴露青少年。我们应用图论指标的静息状态数据，使用来自VSWM任务激活图的节点网络，以进一步探索WM功能的连接性。参与者（年龄12-15岁）包括47名青少年（27名PDE和20名CC）。所有分析均控制了出生特征和产后环境的潜在混杂差异。显著的组间任务差异出现在左额中回（BA 6）与CC组，但不是PDE组，激活该区域在VSWM。PDE组去激活峰，而CC组在VSWM任务期间激活它。CC组表现出显着的反应时间和峰激活之间的关系，不存在于PDE组。基于VSWM性能的网络分析表明，PDE组的全局效率低于CC组，局部效率呈趋势水平下降。与BA 6组任务交互对应的网络节点显示出节点效率降低，与网络中其他节点的直接连接减少。这些结果表明，青春期揭示了与反应计划相关的神经功能改变，这可能反映了PDE青年的网络功能效率较低。
The persistence of effects of prenatal drug exposure (PDE) on brain functioning during adolescence is poorly understood. We explored neural activation to a visuospatial working memory (VSWM) versus a control task using functional magnetic resonance imaging (fMRI) in adolescents with PDE and a community comparison group (CC) of non-exposed adolescents. We applied graph theory metrics to resting state data using a network of nodes derived from the VSWM task activation map to further explore connectivity underlying WM functioning. Participants (ages 12–15 years) included 47 adolescents (27 PDE and 20 CC). All analyses controlled for potentially confounding differences in birth characteristics and postnatal environment. Significant group by task differences in brain activation emerged in the left middle frontal gyrus (BA 6) with the CC group, but not the PDE group, activating this region during VSWM. The PDE group deactivated the culmen, whereas the CC group activated it during the VSWM task. The CC group demonstrated a significant relation between reaction time and culmen activation, not present in the PDE group. The network analysis underlying VSWM performance showed that PDE group had lower global efficiency than the CC group and a trend level reduction in local efficiency. The network node corresponding to the BA 6 group by task interaction showed reduced nodal efficiency and fewer direct connections to other nodes in the network. These results suggest adolescence reveals altered neural functioning related to response planning that may reflect less efficient network functioning in youth with PDE.
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影响因子：
3.4
作者：
Hamilton, Lindsey R.;Czoty, Paul W.;Gage, H. Donald;Nader, Michael A.
通讯作者：
Nader, Michael A.
DOI：
10.1097/01.alc.0000156125.50577.ec
发表时间：
2005-03-01
影响因子：
3.2
作者：
Burden, MJ;Jacobson, SW;Jacobson, JL
通讯作者：
Jacobson, JL
DOI：
10.1073/pnas.1115365109
发表时间：
2012-04-24
影响因子：
11.1
作者：
Fair, Damien A.;Bathula, Deepti;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
影响因子：
9.8
作者：
Bauer, CR;Shankaran, S;Verter, J
通讯作者：
Verter, J
DOI：
10.3758/s13415-012-0100-3
发表时间：
2012-09
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
--
作者：
Basten U;Stelzel C;Fiebach CJ
通讯作者：
Fiebach CJ