The presence of both serotonin 1A receptor (HTR1A) and dopamine transporter (DAT1) gene variants increase the risk of borderline personality disorder.
The presence of both serotonin 1A receptor (HTR1A) and dopamine transporter (DAT1) gene variants increase the risk of borderline personality disorder.
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DOI：
10.3389/fgene.2013.00313
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发表时间：
2014-01-07
影响因子：
3.7
通讯作者：
McHugh PC
中科院分区：
文献类型：
--
作者：
Joyce PR;Stephenson J;Kennedy M;Mulder RT;McHugh PC
多巴胺能神经递质系统和5-羟色胺能神经递质系统的功能障碍在边缘型人格障碍(BPD)的病因学中具有重要意义。我们调查了两个BPD危险因素，HTR1A启动子-1019C>；G(Rs6295)和多巴胺转运体(DAT1)重复等位基因与BPD的关系，在367名抑郁症患者队列中。门诊患有严重抑郁障碍的患者被招募进行两项治疗试验，并评估包括BPD在内的人格障碍。采集DNA样本，用TaqMan®分析法检测rs6295基因多态性。采用改良的聚合酶链式反应方法对DAT1重复等位基因进行分型。采用非控制Logistic回归模型和多元Logistic回归模型对多态对BPD的影响进行统计分析。BPD患者DAT1、9、9(OR=2.67)、9、10(OR=3.67)等位基因频率较高，HTR1AG等位基因纯合频率较高(OR=2.03)。未观察到HTR1A和DAT1基因型之间的显著交互作用；然而，9，10；G，G(OR=6.64)和9，9；C，G(OR=5.42)的患者患BPD的风险增加。此外，表现出这两个基因高危变异的患者患BPD的几率与低风险组患者相差高达9倍。我们的研究提供了证据，表明5-羟色胺和多巴胺能系统在BPD中的重要性，以及来自不同神经递质的基因之间的相互作用可能在BPD的易感性中发挥作用。
Dysfunction in the dopaminergic and serotonergic neurotransmitter systems has been demonstrated to be important in the etiology of borderline personality disorder (BPD). We investigated the relationship of two BPD risk factors, the HTR1A promoter polymorphism -1019C > G (rs6295) and the dopamine transporter (DAT1) repeat allele, with BPD in a major depressive disorder cohort of 367 patients. Out-patients with major depressive disorder were recruited for two treatment trials and assessed for personality disorders, including BPD. DNA samples were collected and the rs6295 polymorphism was detected with a TaqMan® assay. The DAT1 repeat allele was genotyped using a modified PCR method. The impact of polymorphisms on BPD was statistically analyzed using uncontrolled logistic and multiple logistic regression models. BPD patients had higher frequencies of the DAT1 9,9 (OR = 2.67) and 9,10 (OR = 3.67) genotypes and also those homozygous HTR1A G allele (OR = 2.03). No significant interactions between HTR1A and DAT1 genotypes, were observed; however, an increased risk of BPD was observed for those patients who were either 9,10; G,G (OR = 6.64) and 9,9; C,G (OR = 5.42). Furthermore, the odds of BPD in patients exhibiting high-risk variants of these two genes differed from those of patients in low-risk groups by up to a factor of 9. Our study provides evidence implicating the importance of the serotonergic and dopaminergic systems in BPD and that the interaction between genes from different neurotransmitters may play a role in the susceptibility to BPD.
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影响因子：
2.5
作者：
Ni, Xingqun;Bismil, Ramprasad;Kennedy, James L.
通讯作者：
Kennedy, James L.
DOI：
10.1046/j.1440-1614.2001.01026.x
发表时间：
2002-06-01
影响因子：
4.6
作者：
Joyce, PR;Mulder, RT;Stevens, IF
通讯作者：
Stevens, IF
影响因子：
2.9
作者：
CIULLA, TA;SKLAR, RM;HAUSER, SL
通讯作者：
HAUSER, SL
影响因子：
10.5
作者：
Luty, Suzanne E.;Carter, Janet D.;Joyce, Peter R.
通讯作者：
Joyce, Peter R.
影响因子：
7.6
作者：
Friedel, RO
通讯作者：
Friedel, RO