Episodic sitewise positive selection on the signal recognition particle protein Ffh in Actinobacteria

Episodic sitewise positive selection on the signal recognition particle protein Ffh in Actinobacteria
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放线菌中信号识别颗粒蛋白Ffh的间歇式位点正选择

DOI:
10.1016/j.febslet.2010.07.058
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发表时间:
2010-09
期刊:
影响因子:
3.5
通讯作者:
Li, Shan-Zhen
Li, Shan-Zhen
中科院分区:
生物学3区
文献类型:
--
作者:
Li, Yong-Quan;Shen, Xue-Ling;Chen, Xin;Li, Shan-Zhen

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在这项工作中,我们报告的情况下,情节sitewise积极的选择作用于高度保守的SRP蛋白Ffh放线菌。沿着包含11种放线菌的物种树的非末端分支观察到升高的非同义与同义突变比率(ω),其中在信号序列结合结构域内经常观察到正选择残基。结合主要蛋白质易位系统中几个核心组分的估计谱系特异性ω比率,我们的数据表明,这种正选择可能部分由信号序列的多样化驱动。
In this work, we report a case of episodic sitewise positive selection acting on the highly conserved SRP protein Ffh in Actinobacteria. An elevated non-synonymous to synonymous mutation ratio (ω) was observed along the non-terminal branches of the species tree, which contained 11 Actinobacteria species, where positively selected residues were frequently observed within the signal sequence-binding domain. Together with the estimated lineage-specific ω ratios for several core components in the major protein translocation systems, our data suggest that this positive selection might be partially driven by the diversification of signal sequences.
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