Effects of amphetamine and methylphenidate on delay discounting in rats: interactions with order of delay presentation.
Effects of amphetamine and methylphenidate on delay discounting in rats: interactions with order of delay presentation.
复制标题
DOI：
10.1007/s00213-013-3209-3
复制
发表时间：
2014-01
影响因子：
3.4
通讯作者：
France, Charles P.
中科院分区：
文献类型：
--
作者：
Tanno, Takayuki;Maguire, David R.;Henson, Cedric;France, Charles P.
关键词：
药物对延迟折扣的影响被认为反映了对延迟敏感性的变化，尽管可能涉及其他行为机制。揭示不同行为机制的影响的一个策略是改变研究它们的程序的特征。本实验研究了在会话内延迟折扣程序下延迟呈现的顺序是否影响药物对折扣的影响。大鼠在离散试验选择程序下作出反应，其中一个杠杆上的反应立即提供1个食物颗粒，另一个杠杆上的反应立即或延迟后提供3个食物颗粒。延迟到较大的延迟器（0，4，8，16和32秒）是不同的会话内和延迟呈现的顺序（上升或下降）组之间的变化。安非他明（0.1-1.78 mg/kg）和哌醋甲酯（1.0-17.8 mg/kg）使延迟功能在上升组中向上移动（增加对更大延迟器的选择），在下降组中向下移动（减少对更大延迟器的选择）。吗啡（1.0-10.0 mg/kg）和δ-9-四氢大麻酚（0.32-5.6 mg/kg）往往会向下转移延迟功能，无论延迟呈现的顺序如何，从而减少对较大增强剂的选择，即使两种增强剂都被立即输送。安非他明和哌甲酯延迟折扣程序下的影响不同，根据延迟演示的顺序，药物引起的折扣的变化是由于，部分，机制以外的其他改变敏感性的延迟。相反，安非他明和哌醋甲酯改变反应的方式与增加行为持续。
Drug effects on delay discounting are thought to reflect changes in sensitivity to reinforcer delay, although other behavioral mechanisms might be involved. One strategy for revealing the influence of different behavioral mechanisms is to alter features of the procedures in which they are studied. This experiment examined whether the order of delay presentation under within-session delay discounting procedures impacts drug effects on discounting. Rats responded under a discrete-trial choice procedure in which responses on one lever delivered 1 food pellet immediately and responses on the other lever delivered 3 food pellets either immediately or after a delay. The delay to the larger reinforcer (0, 4, 8, 16, and 32 s) was varied within session and the order of delay presentation (ascending or descending) varied between groups. Amphetamine (0.1–1.78 mg/kg) and methylphenidate (1.0–17.8 mg/kg) shifted delay functions upward in the ascending group (increasing choice of the larger reinforcer) and downward in the descending group (decreasing choice of the larger reinforcer). Morphine (1.0–10.0 mg/kg) and delta-9-tetrahydrocannabinol (0.32–5.6 mg/kg) tended to shift the delay functions downward, regardless of order of delay presentation, thereby reducing choice of the larger reinforcer, even when both reinforcers were delivered immediately. The effects of amphetamine and methylphenidate under delay discounting procedures differed depending on the order of delay presentation indicating that drug-induced changes in discounting were due, in part, to mechanisms other than altered sensitivity to reinforcer delay. Instead, amphetamine and methylphenidate altered responding in a manner consistent with increased behavioral perseveration.
登录
查看更多内容
选择性多巴胺能化合物对延迟减少任务的影响。
影响因子：
1.6
作者：
Koffarnus MN;Newman AH;Grundt P;Rice KC;Woods JH
通讯作者：
Woods JH
影响因子：
13.5
作者：
Bickel, Warren K.;Jarmolowicz, David P.;Mueller, E. Terry;Koffarnus, Mikhail N.;Gatchalian, Kirstin M.
通讯作者：
Gatchalian, Kirstin M.
影响因子：
2.7
作者：
Richards, JB;Mitchell, SH;Seiden, LS
通讯作者：
Seiden, LS
影响因子：
3.4
作者：
Kolokotroni, Katerina Zoe;Rodgers, Robert J.;Harrison, Amanda A.
通讯作者：
Harrison, Amanda A.
影响因子：
3.6
作者：
Slezak, Jonathan M.;Anderson, Karen G.
通讯作者：
Anderson, Karen G.