The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.
The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.
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抗菌肽的多面性：目前的合成化学方法和未来的发展方向。
DOI：
10.1039/d0cs00729c
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发表时间：
2021-07-05
影响因子：
46.2
通讯作者：
Spring DR
中科院分区：
文献类型：
--
作者：
Gan BH;Gaynord J;Rowe SM;Deingruber T;Spring DR
由“超级细菌”引起的细菌感染在全球范围内不断增加，传统抗生素对这些细菌的有效性越来越低，以至于我们有可能进入后抗生素时代。近年来，抗菌肽（AMP）作为一种新型的抗耐药性抗生素，其临床应用潜力受到了广泛关注。在这篇综述中，我们讨论了几个方面的抗菌肽，包括他们的多样性，理化性质，作用机制，以及环境因素对这些功能的影响。本文概述了各种化学合成策略，已被应用于开发新的AMP，包括现有肽的化学修饰，半合成，和计算机辅助设计。我们还将强调新的AMP结构，包括杂交，抗菌树枝状聚合物和多肽，肽模拟物，和AMP-药物缀合物，并考虑其化学合成的最新进展。本文综述了抗菌肽及其衍生物的结构和理化性质的多样性，各种化学合成策略，已应用于他们的发展，以及如何这与他们的活动。
Bacterial infections caused by ‘superbugs’ are increasing globally, and conventional antibiotics are becoming less effective against these bacteria, such that we risk entering a post-antibiotic era. In recent years, antimicrobial peptides (AMPs) have gained significant attention for their clinical potential as a new class of antibiotics to combat antimicrobial resistance. In this review, we discuss several facets of AMPs including their diversity, physicochemical properties, mechanisms of action, and effects of environmental factors on these features. This review outlines various chemical synthetic strategies that have been applied to develop novel AMPs, including chemical modifications of existing peptides, semi-synthesis, and computer-aided design. We will also highlight novel AMP structures, including hybrids, antimicrobial dendrimers and polypeptides, peptidomimetics, and AMP–drug conjugates and consider recent developments in their chemical synthesis. This review discusses the diversity of structure and physicochemical properties of antimicrobial peptides and their derivatives, various chemical synthetic strategies that have been applied in their development, and how this links to their activity.
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影响因子：
4.4
作者：
Alvarez-Ordonez, Avelino;Begley, Maire;Hill, Colin
通讯作者：
Hill, Colin
DOI：
10.1165/ajrcmb.20.4.3264
发表时间：
1999-04-01
影响因子：
6.4
作者：
Baconnais, S;Tirouvanziam, R;Puchelle, E
通讯作者：
Puchelle, E
DOI：
10.1016/j.bbrc.2016.03.042
发表时间：
2016-04-08
影响因子：
3.1
作者：
Abram, Sabina Bozic;Aupic, Jana;Jerala, Roman
通讯作者：
Jerala, Roman
影响因子：
3.9
作者：
Aslam B;Wang W;Arshad MI;Khurshid M;Muzammil S;Rasool MH;Nisar MA;Alvi RF;Aslam MA;Qamar MU;Salamat MKF;Baloch Z
通讯作者：
Baloch Z
影响因子：
4.6
作者：
Abdel-Sayed P;Kaeppeli A;Siriwardena T;Darbre T;Perron K;Jafari P;Reymond JL;Pioletti DP;Applegate LA
通讯作者：
Applegate LA