CCL2 and CXCL10 are associated with poor outcome after intracerebral hemorrhage.
CCL2 and CXCL10 are associated with poor outcome after intracerebral hemorrhage.
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CCL2和CXCL10与脑出血后的不良预后相关。
DOI：
10.1002/acn3.595
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发表时间：
2018-08
影响因子：
5.3
通讯作者：
Serum Markers After Spontaneous Cerebral Hemorrhage (SMASCH) Investigators
中科院分区：
文献类型：
--
作者：
Landreneau MJ;Mullen MT;Messé SR;Cucchiara B;Sheth KN;McCullough LD;Kasner SE;Sansing LH;Serum Markers After Spontaneous Cerebral Hemorrhage (SMASCH) Investigators
脑出血具有很高的死亡率，幸存者往往留下严重的残疾。免疫机制可能在出血性脑损伤中发挥重要作用，然而，将这些机制与临床结局联系起来的研究仍然有限。我们的目的是确定与脑出血后的结果相关的血清炎症介质，以便将实验模型的数据转化为患者队列，并确定值得反向翻译的潜在靶点。一项前瞻性队列研究在两个综合性卒中中心招募了自发性脑出血患者。在发病后6、24和72 h采集外周血。在90天时使用改良兰金量表（mRS）评估功能结局。采用多重ELISA检测血清炎症介质。多变量建模确定了与90天功能结局独立相关的血清生物标志物。115名患者完成了研究。在对年龄、性别、ICH体积、IVH、幕下位置和NIHSS评分进行校正后，发作后6 h，CCL 2升高的患者在第90天的mRS评分更差（OR 4.07，95% CI 1.27-13.10，P = 0.02）。在发病后24和72 h，CXCL 10升高与90 d mRS评分恶化独立相关（24 h：OR 8.08，95% CI 2.69-24.30，P < 0.001; 72 h：OR 3.89，95% CI 1.12-13.49，P = 0.03）。特异性免疫因子的急性和亚急性升高与不良结局相关，突出了可能导致脑出血患者持续脑损伤的潜在途径。
Intracerebral hemorrhage carries a high mortality and survivors are frequently left with significant disability. Immunological mechanisms may play an important role in hemorrhage‐induced brain injury, however, research linking these mechanisms with clinical outcome remains limited. We aim to identify serum inflammatory mediators that are associated with outcome after intracerebral hemorrhage in order to translate data from experimental models to a patient cohort and identify potential targets worthy of reverse translation. A prospective cohort study at two comprehensive stroke centers enrolled patients with spontaneous intracerebral hemorrhage. Peripheral blood was collected at 6, 24, and 72 h from onset. Functional outcome was assessed at 90 days using the modified Rankin Scale (mRS). Serum inflammatory mediators were measured using multiplex ELISA. Multivariable modeling identified serum biomarkers independently associated with functional outcome at 90 days. 115 patients completed the study. At 6 h after onset, patients with elevated CCL2 had worse mRS score at day 90 (OR 4.07, 95% CI 1.27–13.10, P = 0.02) after adjusting for age, gender, ICH volume, IVH, infratentorial location and NIHSS score. At 24 and 72 h after onset, elevation in CXCL10 was independently associated with worse 90 days mRS score (24 h: OR 8.08, 95% CI 2.69–24.30, P < 0.001; 72 h: OR 3.89, 95% CI 1.12–13.49, P = 0.03). Acute and subacute elevations in specific immune factors are associated with poor outcome, highlighting potential pathways that may contribute to ongoing brain injury in patients with intracerebral hemorrhage.
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影响因子：
8.3
作者：
Hemphill, JC;Bonovich, DC;Johnston, SC
通讯作者：
Johnston, SC
DOI：
10.1016/j.jstrokecerebrovasdis.2005.06.002
发表时间：
2005-09-01
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
--
作者：
Andersen, Morten Nonboe;Andersen, Klaus Kaae;Olsen, Tom Skyhoj
通讯作者：
Olsen, Tom Skyhoj
DOI：
10.1016/j.jstrokecerebrovasdis.2013.09.006
发表时间：
2014-02
影响因子：
2.5
作者：
Adeoye, Opeolu;Walsh, Kyle;Woo, Jessica G.;Haverbusch, Mary;Moomaw, Charles J.;Broderick, Joseph P.;Kissela, Brett M.;Kleindorfer, Dawn;Flaherty, Matthew L.;Woo, Daniel
通讯作者：
Woo, Daniel
DOI：
10.1016/s1474-4422(12)70104-7
发表时间：
2012-08
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Keep RF;Hua Y;Xi G
通讯作者：
Xi G
影响因子：
9.9
作者：
Castillo, J;Dávalos, A;Kase, CS
通讯作者：
Kase, CS