Serum follicle-stimulating hormone level is associated with human epidermal growth factor receptor type 2 and Ki67 expression in post-menopausal females with breast cancer.
Serum follicle-stimulating hormone level is associated with human epidermal growth factor receptor type 2 and Ki67 expression in post-menopausal females with breast cancer.
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绝经后乳腺癌女性血清促卵泡激素水平与人表皮生长因子受体 2 型和 Ki67 表达相关
DOI：
10.3892/ol.2013.1516
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发表时间：
2013-10
期刊：
影响因子：
2.9
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Zhou J;Chen Y;Huang Y;Long J;Wan F;Zhang S
本研究旨在确定绝经后乳腺癌患者性别激素、促卵泡激素（FSH）、促黄体生成素（LH）、孕酮(P)和催乳素（PRL）水平与两种乳腺癌分子标志物人表皮生长因子受体2 （Her-2）和Ki67的关系。回顾性研究187例绝经后乳腺癌女性患者血清FSH、LH、P、PRL激素水平及Her-2、Ki67表达状况。Her-2阳性乳腺癌患者血清FSH水平高于Her-2阴性患者（69.47±3.219 vs. 58.56±1.516 IU/l）。Ki67高表达[免疫组化（IHC）， 3+]患者FSH（72.51±4.616比60.53±1.476 IU/l）和LH（32.33±1.916比26.98±0.8852 IU/l）水平高于Ki67低表达患者。FSH、LH、P和PRL激素水平与肿瘤分期和淋巴血管侵袭（LVI）无相关性。总之，Her-2阳性绝经后乳腺癌患者血清FSH水平较高。Ki67高表达的乳腺癌患者血清FSH和LH水平也较高。FSH和LH可能在乳腺癌的发展过程中起作用。
The present study aimed to determine the association between levels of the gender hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P) and prolactin (PRL), and two breast cancer molecular markers, human epidermal growth factor receptor 2 (Her-2) and Ki67, in post-menopausal patients with breast cancer. A retrospective study of the serum hormone levels of FSH, LH, P and PRL and the expression status of Her-2 and Ki67 was performed using 187 post-menopausal females with breast cancer. Her-2+ breast cancer patients exhibited higher serum FSH levels compared with Her-2− patients (69.47±3.219 vs. 58.56±1.516 IU/l). The patients with high Ki67 expression [immunohistochemistry (IHC), 3+] displayed higher FSH (72.51±4.616 vs. 60.53±1.476 IU/l) and LH (32.33±1.916 vs. 26.98±0.8852 IU/l) levels than those with lower Ki67 expression. No correlation was identified between the FSH, LH, P and PRL hormone levels, tumor stages and lymphovascular invasion (LVI). In conclusion, a higher serum FSH level was identified in Her-2+ post-menopausal patients with breast cancer. Higher serum FSH and LH levels were also observed in breast cancer patients with high Ki67 expression. FSH and LH may function in the progression of breast cancer.
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影响因子：
4.1
作者：
KELTON, CA;CHENG, SVY;CHAPPEL, SC
通讯作者：
CHAPPEL, SC
雌激素受体阳性可手术乳腺癌：绝经状态会影响 HER2 和孕激素受体状态吗？
影响因子：
3.9
作者：
Wang, Ning;Wang, Bin;Hu, Jia
通讯作者：
Hu, Jia
影响因子：
9.7
作者：
GARDE, SV;SHETH, AR;SHETH, NA
通讯作者：
SHETH, NA
影响因子：
6.2
作者：
Meduri, G;Charnaux, N;Milgrom, E
通讯作者：
Milgrom, E
影响因子：
--
作者：
Wayne, Chad M.;Fan, Heng-Yu;Richards, JoAnne S.
通讯作者：
Richards, JoAnne S.