Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia.
Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia.
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DOI：
10.1186/1471-2393-14-146
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发表时间：
2014-04-23
影响因子：
3.1
通讯作者：
Warburton D
中科院分区：
文献类型：
--
作者：
Enkhmaa D;Warburton N;Javzandulam B;Uyanga J;Khishigsuren Y;Lodoysamba S;Enkhtur S;Warburton D
空气污染是世界范围内的一项重大健康挑战，以前一直与不利的生殖健康密切相关。本研究旨在探讨蒙古乌兰巴托地区自然流产与空气污染物季节变化的关系。蒙古国政府空气质量监测站测量了臭氧、二氧化硫、二氧化氮、一氧化碳、PM10和PM2.5的月平均水平。对2009-2011年间因自然流产入院的1219例妇女的病历资料进行了回顾分析。统计2011年1-12月每个历月的死胎人数，并与各种空气污染物的月平均水平进行回归分析。环境污染物对胎儿死亡的剂量-反应毒性曲线回归显示，二氧化硫r >； 0.9时(p <； 0.001)具有非常强的剂量-反应相关性，而二氧化氮(r >； 0.8时)、一氧化碳(r >； 0.9时)、PM10时(r >； 时时为0.9时)和PM2.5时(r >； 时时)(p <； 时为0.001)的相关系数也非常显著，表明空气污染与胎儿幸福感下降之间存在很强的相关性。目前的研究确定了环境空气污染物和自然流产之间令人震惊的强烈统计相关性。需要进行进一步的研究，以检验个人暴露于空气污染物与妊娠丢失之间的可能相关性。
Air pollution is a major health challenge worldwide and has previously been strongly associated with adverse reproductive health. This study aimed to examine the association between spontaneous abortion and seasonal variation of air pollutants in Ulaanbaatar, Mongolia. Monthly average O3, SO2, NO2, CO, PM10 and PM2.5 levels were measured at Mongolian Government Air Quality Monitoring stations. The medical records of 1219 women admitted to the hospital due to spontaneous abortion between 2009–2011 were examined retrospectively. Fetal deaths per calendar month from January-December, 2011 were counted and correlated with mean monthly levels of various air pollutants by means of regression analysis. Regression of ambient pollutants against fetal death as a dose–response toxicity curve revealed very strong dose–response correlations for SO2 r > 0.9 (p < 0.001) while similarly strongly significant correlation coefficients were found for NO2 (r > 0.8), CO (r > 0.9), PM10 (r > 0.9) and PM2.5 (r > 0.8), (p < 0.001), indicating a strong correlation between air pollution and decreased fetal wellbeing. The present study identified alarmingly strong statistical correlations between ambient air pollutants and spontaneous abortion. Further studies need to be done to examine possible correlations between personal exposure to air pollutants and pregnancy loss.
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