Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada.
Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada.
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DOI：
10.1289/ehp.6251
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发表时间：
2003-11
影响因子：
10.4
通讯作者：
Burnett RT
中科院分区：
文献类型：
--
作者：
Liu S;Krewski D;Shi Y;Chen Y;Burnett RT
环境空气污染与诸如急诊室就诊、住院以及呼吸系统和心血管疾病死亡率等不良健康影响之间的联系，在包括加拿大在内的许多国家都得到了广泛的研究。最近，在捷克共和国和美国中国进行的研究表明，环境空气污染与不良妊娠结局有关。在这项研究中，我们研究了1985-1998年间加拿大温哥华的环境中二氧化硫(SO2)、二氧化氮(NO2)、一氧化碳(CO)和臭氧浓度与早产、低出生体重和宫内生长迟缓(IUGR)之间的关系。使用多元Logistic回归估计这些影响的优势比(OR)和95%可信区间(CI)。低出生体重与怀孕第一个月接触二氧化硫有关(OR=1.11，95%CI，1.01-1.22，增加5.0ppb)。早产与妊娠最后一个月的二氧化硫(OR=1.09，95%CI，1.01-1.19，增加5.0 ppb)和一氧化碳(OR=1.08，95%CI，1.01-1.15，增加1.0ppm)有关。IUGR与妊娠第一个月的SO2(OR=1.07，95%CI，1.01-1.13，增加5.0 ppb)、NO2(OR=1.05，95%CI，1.01-1.10，增加10.0 ppb)和CO(OR=1.06，95%CI，1.01-1.10，增加1.0ppm)有关。总而言之，在经历不同空气污染状况的人群中，相对较低浓度的气态空气污染物与对生育结果的不利影响有关。
The association between ambient air pollution and adverse health effects, such as emergency room visits, hospitalizations, and mortality from respiratory and cardiovascular diseases, has been studied extensively in many countries, including Canada. Recently, studies conducted in China, the Czech Republic, and the United States have related ambient air pollution to adverse pregnancy outcomes. In this study, we examined association between preterm birth, low birth weight, and intrauterine growth retardation (IUGR) among singleton live births and ambient concentrations of sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone in Vancouver, Canada, for 1985-1998. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for such effects. Low birth weight was associated with exposure to SO2 during the first month of pregnancy (OR = 1.11, 95% CI, 1.01-1.22, for a 5.0 ppb increase). Preterm birth was associated with exposure to SO2 (OR = 1.09, 95% CI, 1.01-1.19, for a 5.0 ppb increase) and to CO (OR = 1.08, 95% CI, 1.01-1.15, for a 1.0 ppm increase) during the last month of pregnancy. IUGR was associated with exposure to SO2 (OR = 1.07, 95% CI, 1.01-1.13, for a 5.0 ppb increase), to NO2 (OR = 1.05, 95% CI, 1.01-1.10, for a 10.0 ppb increase), and to CO (OR = 1.06, 95% CI, 1.01-1.10, for a 1.0 ppm increase) during the first month of pregnancy. In conclusion, relatively low concentrations of gaseous air pollutants are associated with adverse effects on birth outcomes in populations experiencing diverse air pollution profiles.
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