The National Women's Health Study: assembly and description of a population-based reproductive cohort.
The National Women's Health Study: assembly and description of a population-based reproductive cohort.
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DOI：
10.1186/1471-2458-4-35
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发表时间：
2004-08-07
影响因子：
4.5
通讯作者：
Prior S
中科院分区：
文献类型：
--
作者：
Maconochie N;Doyle P;Prior S
流产是一种常见的事件，但在流行病学研究中很难测量。在英国很少进行大规模的人口研究。这是一项以人口为基础的两阶段邮政调查，调查对象是2001年居住在英国的成年妇女的生殖史，抽样自电子选民名册。在第一阶段，向随机选择的6万多名妇女发送了一份简短的“筛选”调查表，以便确定55岁及以下曾经怀孕或曾经试图怀孕的妇女，并要求她们提供简短的生育史。第二阶段涉及一份较长的调查表，要求提供关于每一次怀孕（和生育问题）的详细资料，以及关于最近一次怀孕的社会人口、行为和其他因素的问题，以便审查流产的危险因素。将死产、多胎和产妇年龄的数据与国家数据进行比较，以评估反应偏倚。第一阶段的有效率为49%，第二阶段的有效率为73%。第一阶段共回收问卷26,050份。在17,748名符合年龄条件的妇女中，27%的人报告说她们从未怀孕过，也从未试图怀孕。其余13035名妇女总共报告了30661次怀孕。将主要生殖指标（死胎率、多胎率和产妇头胎年龄）与国家统计数据进行比较后发现，这些数据与一般人口的数据非常相似。这项研究使得以人口为基础的女性生殖史数据集的集合成为可能，与一般英国人口相比，这似乎是公正的，这将使调查难以衡量的结果，如流产和不孕症成为可能。
Miscarriage is a common event but is remarkably difficult to measure in epidemiological studies. Few large-scale population-based studies have been conducted in the UK. This was a population-based two-stage postal survey of reproductive histories of adult women living in the United Kingdom in 2001, sampled from the electronic electoral roll. In Stage 1 a short "screening" questionnaire was sent to over 60,000 randomly selected women in order to identify those aged 55 and under who had ever been pregnant or ever attempted to achieve a pregnancy, from whom a brief reproductive history was requested. Stage 2 involved a more lengthy questionnaire requesting detailed information on every pregnancy (and fertility problems), and questions relating to socio-demographic, behavioural and other factors for the most recent pregnancy in order to examine risk factors for miscarriage. Data on stillbirth, multiple birth and maternal age are compared to national data in order to assess response bias. The response rate was 49% for Stage 1 and 73% for the more targeted Stage 2. A total of 26,050 questionnaires were returned in Stage 1. Of the 17,748 women who were eligible on the grounds of age, 27% reported that they had never been pregnant and had never attempted to conceive a child. The remaining 13,035 women reported a total of 30,661 pregnancies. Comparison of key reproductive indicators (stillbirth and multiple birth rates and maternal age at first birth) with national statistics showed that the data look remarkably similar to the general population. This study has enabled the assembly of a large population-based dataset of women's reproductive histories which appears unbiased compared to the general UK population and which will enable investigation of hard-to-measure outcomes such as miscarriage and infertility.
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影响因子：
4.5
作者：
Maconochie, N;Doyle, P;Davies, G;Lewis, S;Pelerin, M;Prior, S;Sampson, P
通讯作者：
Sampson, P
影响因子：
4.9
作者：
Roman, E;Doyle, P;Beral, V
通讯作者：
Beral, V
影响因子：
5.4
作者：
Li, DK;Odouli, R;Iriye, R
通讯作者：
Iriye, R
影响因子：
5
作者：
Osborn, JF;Cattaruzza, MS;Spinelli, A
通讯作者：
Spinelli, A
影响因子：
--
作者：
Andersen, AMN;Wohlfahrt, J;Melbye, M
通讯作者：
Melbye, M