The study of reproductive outcome and the health of offspring of UK veterans of the Gulf war: methods and description of the study population.
The study of reproductive outcome and the health of offspring of UK veterans of the Gulf war: methods and description of the study population.
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对海湾战争英国退伍军人的生殖结果和后代的健康研究：研究人群的方法和描述。
DOI：
10.1186/1471-2458-3-4
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发表时间：
2003-01-10
影响因子：
4.5
通讯作者：
Sampson, P
中科院分区：
文献类型：
--
作者：
Maconochie, N;Doyle, P;Davies, G;Lewis, S;Pelerin, M;Prior, S;Sampson, P
这项研究的目的是确定海湾战争退伍军人及其伴侣是否有不良生殖事件的风险增加，以及他们的孩子是否有严重健康问题的风险增加。本文报告了该研究的方法和反应。这是一项回顾性队列研究，研究对象为英国海湾战争退伍军人，并与未部署到海湾地区的武装部队人员进行比较。生殖史和儿童健康的详细情况通过有效的邮寄问卷收集。对无应答者进行了单独研究。共有25，084名海湾战争退伍军人（24，379名男性）和19，003名（18，439名男性）对照组的受试者返回了样本。在调整了未送达邮件后，海湾战争退伍军人的回复率为53%，男性为42%，女性为72%和60%。来自无应答者研究的数据表明，对主要调查的不应答在很大程度上与生殖无关。自海湾战争以来，11，155名（46%）男性海湾战争退伍军人和7，769名（42%）男性非海湾战争退伍军人怀孕或试图怀孕。在此期间，他们分别报告了16442例和11517例妊娠。对于女性，313名（44%）海湾退伍军人和235名（42%）非海湾退伍军人报告自海湾战争以来分别怀孕484次和377次。这项调查能够收集信息的一系列生殖结果从退伍军人的海湾战争和适当匹配的比较队列。虽然男性的回答率令人失望，选择偏见有关的生殖似乎并不强，在这些数据。
The aim of this study is to determine whether Gulf war veterans and their partners are at increased risk of adverse reproductive events and whether their children have increased risk of serious health problems. Methods and response to the study are reported here. This was a retrospective cohort study of reproduction among UK Gulf war veterans, with a comparison cohort of Armed Service personnel who were not deployed to the Gulf. Reproductive history and details of children's health was collected by means of a validated postal questionnaire. A separate study of non-responders was conducted. Questionnaires were returned by a total of 25,084 Gulf war veterans (24,379 men) and 19,003 (18,439 men) subjects in the comparison group. After adjusting for undelivered mail the response rate was 53% for Gulf war veterans and 42% for non-Gulf veterans among men, 72% and 60% among women. Data from the non-responder study suggests that failure to respond to the main survey was largely unrelated to reproduction. 11,155 (46%) male Gulf war veterans and 7,769 (42%) male non-Gulf war veterans had conceived, or attempted to conceive, since the Gulf war. They reported 16442 and 11517 pregnancies respectively in that period. For women, 313 (44%) Gulf veterans and 235 (42%) non-Gulf veterans reported 484 and 377 pregnancies respectively conceived since the Gulf war. This survey enabled collection of information on a range of reproductive outcomes from veterans of the Gulf war and a suitably matched comparison cohort. Although the response rate for men was disappointing, selection bias related to reproduction does not appear to be strong in these data.
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影响因子：
4.9
作者：
Roman, E;Doyle, P;Beral, V
通讯作者：
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