Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.
Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.
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全身IFN-α在B6.SLE123小鼠中驱动肾脏肾炎。
DOI：
10.1002/eji.200837925
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发表时间：
2008-07
影响因子：
5.4
通讯作者：
Wakeland, Edward K.
中科院分区：
文献类型：
--
作者：
Fairhurst, Anna-Marie;Mathian, Alexis;Connolly, John E.;Wang, Andrew;Gray, Hillery F.;George, Tiffany A.;Boudreaux, Christopher D.;Zhou, Xin J.;Li, Quan-Zhen;Koutouzov, Sophie;Banchereau, Jacques;Wakeland, Edward K.
用含有重组干扰素α基因盒的腺病毒表达载体比较狼疮易感株B6.Sle1Sle2Sle3(B6.Sle123)和亲本B6同源伴侣的表型变化，评价干扰素α的分泌对疾病进展的影响。对年轻的B6和B6.Sle123小鼠的细胞谱系组成和激活进行了全面的比较，发现在存在和不存在系统性干扰素α的情况下，细胞发生了各种各样的变化。大多数干扰素α诱导的表型在B6和B6Sle123中相似，然而，B6.Sle123小鼠在干扰素α暴露后独特地表现出B1细胞和浆细胞的增加，尽管两个菌株的骨髓、脾和外周的成熟B细胞总体上都丢失了。虽然干扰素α的大部分细胞效应在两个品系中是相同的，但严重的GN只发生在B6.Sle123小鼠。注射干扰素-ADV的小鼠肾脏中免疫复合体沉积增加，同时血清ANA水平意外下降。总之，在这个小鼠模型中，全身干扰素α的主要影响是加剧了调节终末器官损伤的机制。
The impact of IFNα secretion on disease progression was assessed by comparing phenotypic changes in the lupus-prone B6.Sle1Sle2Sle3 (B6.Sle123) strain and the parental B6 congenic partner using an adenovirus expression vector containing a recombinant IFNα gene cassette (IFN-ADV). A comprehensive comparison of cell lineage composition and activation in young B6 and B6.Sle123 mice revealed a variety of cellular alterations in the presence and absence of systemic IFNα. Most IFNα-induced phenotypes were similar in B6 and B6.Sle123, however, B6.Sle123 mice uniquely exhibited increased B1 and plasma cells after IFNα exposure, although both strains had an overall loss of mature B cells in the bone marrow, spleen and periphery. Although most of the cellular effects of IFNα were identical in both strains, severe GN only occurred in B6.Sle123 mice. Mice injected with IFN-ADV showed an increase in immune complex deposition in the kidney, together with an unexpected decrease in serum ANA levels. In summary, the predominant impact of systemic IFNα in this murine model is an exacerbation of mechanisms mediating end organ damage.
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脾脏中的B细胞发育发生在离散的步骤中，并取决于B细胞受体衍生的信号的质量。
影响因子：
15.3
作者：
Loder, F;Mutschler, B;Ray, R J;Paige, C J;Sideras, P;Torres, R;Lamers, M C;Carsetti, R
通讯作者：
Carsetti, R
DOI：
10.1084/jem.187.1.79
发表时间：
1998-01-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lin Q;Dong C;Cooper MD
通讯作者：
Cooper MD
DOI：
10.1084/jem.20021553
发表时间：
2003-03-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bennett L;Palucka AK;Arce E;Cantrell V;Borvak J;Banchereau J;Pascual V
通讯作者：
Pascual V
影响因子：
56.9
作者：
Blanco, P;Palucka, AK;Banchereau, J
通讯作者：
Banchereau, J
影响因子：
--
作者：
Kirou, KA;Lee, C;Crow, MK
通讯作者：
Crow, MK