Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study.
Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study.
复制标题
DOI：
10.1186/1475-2840-11-34
复制
发表时间：
2012-07-11
影响因子：
9.3
通讯作者：
Chambers ST
中科院分区：
文献类型：
--
作者：
Lever M;Slow S;McGregor DO;Dellow WJ;George PM;Chambers ST
由于甜菜碱是一种渗透剂和甲基供体，并且甜菜碱的异常损失在糖尿病患者中很常见（>20%的患者），我们研究了甜菜碱与糖尿病和对照受试者中同型半胱氨酸的蛋氨酸后负荷升高之间的关系。据报道，蛋氨酸负荷试验后是一个独立的血管危险因素和甜菜碱充足的措施。招募了2型糖尿病患者（n = 34）和对照受试者（n = 17）。我们测量了基线空腹血浆和蛋氨酸负荷后4小时（L-蛋氨酸，0.1 mg/kg体重）同型半胱氨酸，甜菜碱和甜菜碱代谢产物N，N-二甲基甘氨酸的浓度。基线尿排泄的甜菜碱，二甲基甘氨酸和葡萄糖测量晨尿样本作为尿肌酐的比例。在多元线性回归模型中确定了蛋氨酸负荷后同型半胱氨酸增加的统计决定因素。与对照组相比，糖尿病患者血浆甜菜碱浓度和尿甜菜碱排泄量变化更大（p < 0.001）。二甲基甘氨酸排泄（p = 0.00014）和血浆二甲基甘氨酸浓度（p = 0.039）也更易变。在糖尿病中，血浆甜菜碱是蛋氨酸后同型半胱氨酸负荷增加的显著负决定因素（p < 0.001）。然而，这与对照组中的关系不同并不确定。在糖尿病患者中，尿甜菜碱排泄量与尿糖排泄量（但不与血糖）之间存在密切关系。高和低的血浆甜菜碱浓度，以及高和低的尿甜菜碱排泄，在糖尿病中更普遍。甜菜碱的可用性影响甲硫氨酸负荷试验中的响应。应研究增加甜菜碱摄入量的益处。
Since betaine is an osmolyte and methyl donor, and abnormal betaine loss is common in diabetes mellitus (>20% patients), we investigated the relationship between betaine and the post-methionine load rise in homocysteine, in diabetes and control subjects. The post-methionine load test is reported to be both an independent vascular risk factor and a measure of betaine sufficiency. Patients with type 2 diabetes (n = 34) and control subjects (n = 17) were recruited. We measured baseline fasting plasma and 4-hour post-methionine load (L-methionine, 0.1 mg/kg body weight) concentrations of homocysteine, betaine, and the betaine metabolite N,N-dimethylglycine. Baseline urine excretions of betaine, dimethylglycine and glucose were measured on morning urine samples as the ratio to urine creatinine. Statistical determinants of the post-methionine load increase in homocysteine were identified in multiple linear regression models. Plasma betaine concentrations and urinary betaine excretions were significantly (p < 0.001) more variable in the subjects with diabetes compared with the controls. Dimethylglycine excretion (p = 0.00014) and plasma dimethylglycine concentrations (p = 0.039) were also more variable. In diabetes, plasma betaine was a significant negative determinant (p < 0.001) of the post-methionine load increase in homocysteine. However, it was not conclusive that this was different from the relationship in the controls. In the patients with diabetes, a strong relationship was found between urinary betaine excretion and urinary glucose excretion (but not with plasma glucose). Both high and low plasma betaine concentrations, and high and low urinary betaine excretions, are more prevalent in diabetes. The availability of betaine affects the response in the methionine load test. The benefits of increasing betaine intake should be investigated.
登录
查看更多内容
影响因子：
2.8
作者：
Lever, Michael;Atkinson, Wendy;Chambers, Stephen T.
通讯作者：
Chambers, Stephen T.
影响因子：
4.8
作者：
Park, EI;Garrow, TA
通讯作者：
Garrow, TA
影响因子：
5
作者：
LEVER, M;SIZELAND, PCB;CHAMBERS, ST
通讯作者：
CHAMBERS, ST
DOI：
10.1152/ajpregu.00406.2004
发表时间：
2005-01-01
影响因子：
2.8
作者：
Delgado-Reyes, CV;Garrow, TA
通讯作者：
Garrow, TA
影响因子：
7.1
作者：
Atkinson, Wendy;Elmslie, Jane;George, Peter M.
通讯作者：
George, Peter M.