Early life adversity blunts responses to pioglitazone in depressed, overweight adults.
Early life adversity blunts responses to pioglitazone in depressed, overweight adults.
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DOI：
10.1016/j.eurpsy.2018.09.009
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Rasgon NL
中科院分区：
文献类型：
--
作者：
Robakis TK;Watson-Lin K;Wroolie TE;Myoraku A;Nasca C;Bigio B;McEwen B;Rasgon NL
目的：早期生活逆境与成年后的代谢障碍和抑郁症有关，也与抗抑郁药物的不良反应有关。目前尚不清楚抗糖尿病药物敏感性的个体差异是否也与早期生活逆境有关。我们研究了早期生活逆境的历史是否会影响所观察到的代谢功能和抑郁症状的变化，在一项随机试验中吡格列酮为增强的标准治疗depress.Purpose：早期生活逆境与代谢障碍和抑郁症在成年期，以及与不良反应的抗抑郁药物。目前尚不清楚抗糖尿病药物敏感性的个体差异是否也与早期生活逆境有关。我们研究了早期生活逆境的历史是否会影响所观察到的代谢功能和抑郁症状的变化，在一项随机试验的吡格列酮为增强的标准治疗depression.Findings：我们发现，早期生活逆境显着损害吡格列酮的代谢反应。对抑郁症状的影响并未达到显着水平，但仍表明吡格列酮可以减轻童年逆境的抑郁作用，仅在基线胰岛素抵抗的人群中。结论：我们得出的结论是，早期生活逆境史可能会损害身体对胰岛素的反应能力增敏药物治疗，此外，它对抵抗性抑郁症的贡献可能部分通过胰岛素抵抗表型的产生来发挥作用。
Purpose:Early life adversity is associated with both metabolic impairment and depression in adulthood, as well as with poorer responses to antidepressant medications. It is not yet known whether individual differences in sensitivity to antidiabetic medications could also be related to early life adversity. We examined whether a history of early life adversity affected the observed changes in metabolic function and depressive symptoms in a randomized trial of pioglitazone for augmentation of standard treatments for depression.Purpose:Early life adversity is associated with both metabolic impairment and depression in adulthood, as well as with poorer responses to antidepressant medications. It is not yet known whether individual differences in sensitivity to antidiabetic medications could also be related to early life adversity. We examined whether a history of early life adversity affected the observed changes in metabolic function and depressive symptoms in a randomized trial of pioglitazone for augmentation of standard treatments for depression.Findings:We found that early life adversity significantly impaired the metabolic response to pioglitazone. Effects on depressive symptoms did not reach significance, but nonetheless suggested that pioglitazone could mitigate the depressant effects of childhood adversity, only among those insulin resistant at baseline.Conclusions:We conclude that a history of early life adversity may impair the body’s ability to respond to insulin sensitizing pharmacotherapy, and furthermore that its contribution to resistant depression may function in part via the generation of an insulin resistant phenotype.
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DOI：
10.1038/oby.2010.327
发表时间：
2011-08
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Shea MK;Nicklas BJ;Marsh AP;Houston DK;Miller GD;Isom S;Miller ME;Carr JJ;Lyles MF;Harris TB;Kritchevsky SB
通讯作者：
Kritchevsky SB
影响因子：
3
作者：
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通讯作者：
Egede, Leonard
影响因子：
10.6
作者：
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通讯作者：
Lanctot, Krista L.
DOI：
10.1073/pnas.1202835109
发表时间：
2012-07-24
影响因子：
11.1
作者：
Liu, Jing;Guo, Ming;Lu, Xin-Yun
通讯作者：
Lu, Xin-Yun
影响因子：
11
作者：
Baumeister D;Akhtar R;Ciufolini S;Pariante CM;Mondelli V
通讯作者：
Mondelli V