The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss.
The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss.
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DOI：
10.1038/oby.2010.327
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Kritchevsky SB
中科院分区：
文献类型：
--
作者：
Shea MK;Nicklas BJ;Marsh AP;Houston DK;Miller GD;Isom S;Miller ME;Carr JJ;Lyles MF;Harris TB;Kritchevsky SB
异位脂肪堆积的增加与代谢和心血管疾病以及身体残疾的风险增加有关。减少骨骼肌脂肪和保留瘦肉组织与老年人身体功能的改善有关。PPARγ激动剂治疗减少腹部内脏脂肪组织（VAT），阻力训练保留瘦肉组织，但它们对非糖尿病超重成人异位脂肪库的影响尚不清楚。我们研究了吡格列酮和抗阻训练对老年（65-79岁）非糖尿病超重/肥胖男性（n = 48，BMI = 32.3 ± 3.8 kg/m2）和女性（n = 40，BMI = 33.3 ± 4.9 kg/m2）体重减轻期间身体组成的影响。所有参与者均接受了为期16周的低热量减肥计划，并按照2 × 2析因设计随机接受吡格列酮（30 mg/天）或不接受吡格列酮，伴或不伴阻力训练。在基线和随访时使用计算机断层扫描（CT）测量局部身体组成。使用双X线吸收法测量瘦体重。男性减少了6.6%，女性减少了6.5%的初始体重。脂肪损失的百分比在各个隔室中变化。服用吡格列酮的男性比未服用吡格列酮的男性减少更多的内脏腹部脂肪（-1，160 vs.-647 cm 3，P = 0.007）。服用吡格列酮的女性大腿皮下脂肪减少较少（-104 vs.-298 cm 3，P = 0.002）。吡格列酮不影响任何其他结局。阻力训练减少了男性和女性的大腿肌肉损失（阻力训练与无阻力训练男性：-43 vs.-88 cm 3，P = 0.005;女性：-34 vs.-59 cm 3，P = 0.04）。在超重/肥胖的老年男性中，吡格列酮增加了内脏脂肪的减少，阻力训练减少了骨骼肌的减少。需要更多的研究来澄清观察到的性别差异，并评估这些身体成分的变化如何影响功能状态。
Age-related increases in ectopic fat accumulation are associated with greater risk for metabolic and cardiovascular diseases, and physical disability. Reducing skeletal muscle fat and preserving lean tissue are associated with improved physical function in older adults. PPARγ-agonist treatment decreases abdominal visceral adipose tissue (VAT) and resistance training preserves lean tissue, but their effect on ectopic fat depots in nondiabetic overweight adults is unclear. We examined the influence of pioglitazone and resistance training on body composition in older (65–79 years) nondiabetic overweight/obese men (n = 48, BMI = 32.3 ± 3.8 kg/m2) and women (n = 40, BMI = 33.3 ± 4.9 kg/m2) during weight loss. All participants underwent a 16-week hypocaloric weight-loss program and were randomized to receive pioglitazone (30 mg/day) or no pioglitazone with or without resistance training, following a 2 × 2 factorial design. Regional body composition was measured at baseline and follow-up using computed tomography (CT). Lean mass was measured using dual X-ray absorptiometry. Men lost 6.6% and women lost 6.5% of initial body mass. The percent of fat loss varied across individual compartments. Men who were given pioglitazone lost more visceral abdominal fat than men who were not given pioglitazone (−1,160 vs. −647 cm3, P = 0.007). Women who were given pioglitazone lost less thigh subcutaneous fat (−104 vs. −298 cm3, P = 0.002). Pioglitazone did not affect any other outcomes. Resistance training diminished thigh muscle loss in men and women (resistance training vs. no resistance training men: −43 vs. −88 cm3, P = 0.005; women: −34 vs. −59 cm3, P = 0.04). In overweight/obese older men undergoing weight loss, pioglitazone increased visceral fat loss and resistance training reduced skeletal muscle loss. Additional studies are needed to clarify the observed gender differences and evaluate how these changes in body composition influence functional status.
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DOI：
10.1016/j.ecl.2008.09.002
发表时间：
2008-12
影响因子：
4.5
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
16.2
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4
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DOI：
10.1016/j.numecd.2009.01.010
发表时间：
2009-12-01
影响因子：
3.9
作者：
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