The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial.
The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial.
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DOI：
10.1371/journal.pone.0188171
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Morita M
中科院分区：
文献类型：
--
作者：
Mizuno H;Ekuni D;Maruyama T;Kataoka K;Yoneda T;Fukuhara D;Sugiura Y;Tomofuji T;Wada J;Morita M
本研究的目的是调查非手术牙周治疗对2型糖尿病（T2 DM）患者血红蛋白A1 c（HbA 1c）水平、氧化应激平衡和生活质量（QOL）的影响，并与未进行牙周治疗（仅提供简单的口腔卫生指导）进行比较。设计为6个月、单盲、单中心、随机临床试验。患者同时患有T2 DM和慢性牙周炎。2014年4月至2016年3月期间，在冈山大学医院肾脏病、糖尿病和内分泌科招募了40名参与者。牙周治疗组（n = 20）接受非手术牙周治疗，包括洁治、根面平整术和口腔卫生指导，并在3个月和6个月时连续进行牙周支持治疗。对照组（n = 17）在实验期间只接受口腔卫生指导而不进行治疗。主要研究结局是HbA 1c水平从基线至3个月的变化。次要结果包括氧化应激平衡（氧化指数），糖尿病治疗相关的QOL和临床牙周参数从基线到3个月和基线到6个月的变化。牙周治疗组3个月和6个月时的HbA 1c变化与对照组无显著差异。牙周治疗组的全身氧化应激平衡和生活质量在3个月时比对照组显著改善。在亚组分析（糖尿病控制中度差）中，牙周治疗组的HbA 1c水平在3个月时的下降幅度大于对照组，但不显著。在T2 DM患者中，非手术牙周治疗改善了全身氧化应激平衡和QOL，但在3个月随访时没有降低HbA 1c水平。当前对照试验UMIN-ICDR UMIN 000013278（2014年4月1日注册）。
The purpose of this study was to investigate the effects of non-surgical periodontal treatment on hemoglobinA1c (HbA1c) levels, oxidative stress balance and quality of life (QOL) in patients with type 2 diabetes mellitus (T2DM) compared to no periodontal treatment (simple oral hygiene instructions only). The design was a 6-month, single-masked, single center, randomized clinical trial. Patients had both T2DM and chronic periodontitis. Forty participants were enrolled between April 2014 and March 2016 at the Nephrology, Diabetology and Endocrinology Department of Okayama University Hospital. The periodontal treatment group (n = 20) received non-surgical periodontal therapy, including scaling and root planing plus oral hygiene instructions, and consecutive supportive periodontal therapy at 3 and 6 months. The control group (n = 17) received only oral hygiene instructions without treatment during the experimental period. The primary study outcome was the change in HbA1c levels from baseline to 3 months. Secondary outcomes included changes in oxidative stress balance (Oxidative-INDEX), the Diabetes Therapy-Related QOL and clinical periodontal parameters from baseline to 3 months and baseline to 6 months. Changes in HbA1c in the periodontal treatment group were not significantly different with those in the control group at 3 and 6 months. Systemic oxidative stress balance and QOL significantly improved in the periodontal treatment group compared to the control group at 3 months. In the subgroup analysis (moderately poor control of diabetes), the decrease in HbA1c levels in the periodontal treatment group was greater than that in the control group at 3 months but not significant. In T2DM patients, non-surgical periodontal treatment improved systemic oxidative stress balance and QOL, but did not decrease HbA1c levels at 3 months follow-up. Current Controlled Trials UMIN-ICDR UMIN 000013278 (Registered April 1, 2014).
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DOI：
10.3390/antiox4030513
发表时间：
2015-07-09
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Azuma T;Yamane M;Ekuni D;Kawabata Y;Kataoka K;Kasuyama K;Maruyama T;Tomofuji T;Morita M
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4.6
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影响因子：
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