Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk.
Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk.
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DOI：
10.1016/j.metabol.2014.06.001
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发表时间：
2014-10
影响因子：
9.8
通讯作者：
Mantzoros, Christos S.
中科院分区：
文献类型：
--
作者：
Panagiotou, Grigorios;Mu, Lin;Na, Brian;Mukamal, Kenneth J.;Mantzoros, Christos S.
关键词：
肌肉和脂肪现在被认为是调节代谢的内分泌器官。然而，肌肉和脂肪细胞衍生的新型细胞因子，如鸢尾素和omentin-1与心血管风险相关的代谢生物标志物的关系仍然研究不足。39名平均（±SD）BMI为29.2±5.4 kg/m2且有糖尿病或其他两种心血管风险因素的受试者入组了一项为期6个月的低剂量乙醇随机试验。我们检查了基线、3个月和6个月随访时的横断面数据，以评估（1）新型细胞因子（鸢尾素、网膜素-1、内脂素、β-内酰胺酶和可溶性肿瘤坏死因子受体II）的个体内稳定性和（2）它们与代谢参数的相关性，特别是脂蛋白亚颗粒谱。重复测量的鸢尾素和网膜素-1高度相关，组内相关系数分别为0.84（95%CI：0.74，0.91; P<0.001）和0.81（0.70，0.89; P<0.001）。鸢尾素与网膜素-1呈负相关（网膜素-1每增加1-SD，鸢尾素减少7.4%; 95% CI：0.5%，13.9%; P=0.04）。在校正了年龄、性别和种族的模型中，鸢尾素与HDL胆固醇（每增加10 mg/dL降低7.3%; 1.0%，13.3%; P=0.02）和大HDL颗粒（每增加1-SD或3.5 μmol/L降低15.5%; 5.2%，24.7%; P=0.005）呈负相关。网膜素-1与平均VLDL大小正相关（每增加1-SD增加3.8%; 0.06%，7.8%; P=0.05）。酒精干预、BMI和其他细胞因子的调整对这些关联没有实质性影响。Irisin和omentin-1在体内稳定，相互呈负相关，并与脂蛋白谱密切相关。这些分子可能是心血管风险的有前途的标志物。
Muscle and fat are now recognized as metabolism-regulating endocrine organs. However, muscle and adipocyte-derived novel cytokines such as irisin and omentin-1 remain understudied in relation to metabolic biomarkers that are associated with cardiovascular risk. Thirty-nine subjects with mean (±SD) BMI of 29.2±5.4 kg/m2 and either diabetes or two other cardiovascular risk factors were enrolled in a 6-month randomized trial of low-dose ethanol. We examined cross-sectional data at baseline, 3-month, and 6-month visits to assess (1) within-person stability of novel cytokines (irisin, omentin-1, visfatin, resistin, and soluble tumor necrosis factor receptor II) and (2) their associations with metabolic parameters, particularly lipoprotein subparticle profile. Repeated measures of irisin and omentin-1 were highly correlated, with intra-class correlations of 0.84 (95% CI: 0.74, 0.91; P<0.001) and 0.81 (0.70, 0.89; P<0.001), respectively. Irisin was negatively correlated with omentin-1 (7.4% irisin decrease per a 1-SD increment in omentin-1; 95% CI: 0.5%, 13.9%; P=0.04). In models adjusted for age, sex, and race, irisin was negatively associated with HDL cholesterol (7.3% decrease per a 10 mg/dL increment; 1.0%, 13.3%; P=0.02) and large HDL particles (15.5% decrease per a 1-SD or 3.5-μmol/L increment; 5.2%, 24.7%; P=0.005). Omentin-1 was positively associated with mean VLDL size (3.8% increase per a 1-SD increment; 0.06%, 7.8%; P=0.05). Adjustment for alcohol intervention, BMI, and other cytokines did not materially affect these associations. Irisin and omentin-1 are stable within-person, inversely associated with each other, and closely related to lipoprotein profile. These molecules may be promising markers for cardiovascular risk.
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