Incidence of constipation and associated factors in the period of lockdown during COVID-19 pandemic: protocol for a systematic review and meta-analysis.
Incidence of constipation and associated factors in the period of lockdown during COVID-19 pandemic: protocol for a systematic review and meta-analysis.
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DOI：
10.1136/bmjopen-2022-069614
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发表时间：
2023-09-29
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
由于隔离措施而出现的生活方式和习惯的变化可能对排便习惯产生了负面影响。然而，缺乏对其发生和流行的综合估计数据。系统检索PubMed/MEDLINE、Web of Science、Cochrane图书馆、EMbase、CNKI、SinoMed、维普·中国科技期刊数据库、中国生物医学数据库和万方数据。搜索将包括从数据库成立到2022年9月发表的文献。两位作者将独立筛选文章，并根据预先定义的纳入和排除标准提取数据。纳入研究中的偏差风险将使用纽卡斯尔-渥太华观察性研究量表进行评估。统计分析将使用Review Manager软件V.5.4和Stata V.16.0软件进行。研究之间的异质性将使用Q统计检验和I2统计检验进行评估。在异质性显著的情况下，将进行亚群分析和敏感性分析，以探寻异质性的来源。还将进行敏感性分析，以评估研究结果的可靠性。如果可行，将进行荟萃分析。否则，将使用最佳证据合成方法进行描述性合成。令人感兴趣的主要结果将是便秘的流行。次要结果将包括检查风险因素之间的关联。为了评估潜在的出版偏倚，我们将同时使用贝格漏斗图和艾格的加权回归统计。此外，为了准确评估我们初步结果的证据质量，我们将使用建议评级评估、开发和评估系统。这一系统回顾方案将只考虑数据库中可用的已发表研究，不包括患者个人数据。因此，不需要伦理上的批准，研究结果将发表在同行评议的期刊上。CRD42022366176。
The lifestyle and habit changes that have emerged as a result of quarantine measures may have had a negative impact on defecation habits. However, there is a lack of data on combined estimates of its occurrence and prevalence. We will conduct a systematic search for observational studies on PubMed/MEDLINE, Web of Science, Cochrane Library, EMBASE, CNKI, SinoMed, VIP China Science and Technology Journal database, Chinese Biomedical Databases and Wanfang Data. The search will include literature published from the inception of the databases to September 2022. Two authors will independently screen articles and extract data based on predefined inclusion and exclusion criteria. The risk of bias in the included studies will be evaluated using the Newcastle-Ottawa Scale for observational studies. Statistical analysis will be performed using Review Manager software V.5.4 and STATA V.16.0 software. Heterogeneity among studies will be assessed using the Q statistical test and I2 statistical tests. In case of significant heterogeneity, subgroup analysis and sensitivity analysis will be conducted to explore the source of heterogeneity. Sensitivity analyses will also be performed to assess the reliability of the study findings. If feasible, a meta-analysis will be conducted. Otherwise, a descriptive synthesis will be performed using a best-evidence synthesis approach. The primary outcome of interest will be the prevalence of constipation. The secondary outcomes will involve examining the association of risk factors. To evaluate potential publication bias, we will use both the Begg funnel plot and Egger’s weighted regression statistics. Furthermore, to accurately assess the quality of evidence for our primary outcome, we will employ the Grading of Recommendations Assessment, Development and Evaluation system. This systematic review protocol will only consider published studies available in databases and will not include individual patient data. Therefore, ethical approval is not required, and the findings will be published in a peer-reviewed journal. CRD42022366176.
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