Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.
Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.
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DOI：
10.1111/gbb.12447
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Su J
中科院分区：
文献类型：
--
作者：
Dick DM;Barr PB;Cho SB;Cooke ME;Kuo SI;Lewis TJ;Neale Z;Salvatore JE;Savage J;Su J
随着精神病学遗传学进入一个基因识别最终产生强大的、可复制的遗传关联和多基因风险得分的时代，重要的是考虑下一步行动，并描述如何将这些知识应用于最终缓解与药物使用和精神障碍相关的痛苦。后Gwas的大部分讨论都集中在遗传信息阐明潜在生物学和利用这些信息开发更有效的药物治疗上的潜力。在这篇综述中，我们将重点放在基因鉴定之后应该进行的其他研究领域。通过将遗传研究结果纳入纵向发展研究，我们可以绘制出遗传风险在发育过程中表现出来的路径，阐明风险的早期行为表现，并研究不同环境和干预措施如何在发育阶段缓和这种风险。跨发展风险的描述将促进我们对不同种族/民族群体中的机制、性别差异以及风险和复原力过程的理解。在这里，我们回顾了现有的双胞胎研究文献如何可以用来指导这些努力。总而言之，这些新的研究方向将使我们能够制定更知情、更有针对性的预防和干预努力。
As psychiatric genetics enters an era where gene identification is finally yielding robust, replicable genetic associations and polygenic risk scores, it is important to consider next steps and delineate how that knowledge will be applied to ultimately ameliorate suffering associated with substance use and psychiatric disorders. Much of the post-GWAS discussion has focused on the potential of genetic information to elucidate the underlying biology and use this information for the development of more effective pharmaceutical treatments. In this review we focus on additional areas of research that should follow gene identification. By taking genetic findings into longitudinal, developmental studies, we can map the pathways by which genetic risk manifests across development, elucidating the early behavioral manifestations of risk, and studying how various environments and interventions moderate that risk across developmental stages. The delineation of risk across development will advance our understanding of mechanism, sex differences, and risk and resilience processes in different racial/ethnic groups. Here, we review how the extant twin study literature can be used to guide these efforts. Together, these new lines of research will enable us to develop more informed, tailored prevention and intervention efforts.
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影响因子：
25
作者：
Breen G;Li Q;Roth BL;O'Donnell P;Didriksen M;Dolmetsch R;O'Reilly PF;Gaspar HA;Manji H;Huebel C;Kelsoe JR;Malhotra D;Bertolino A;Posthuma D;Sklar P;Kapur S;Sullivan PF;Collier DA;Edenberg HJ
通讯作者：
Edenberg HJ
影响因子：
25.8
作者：
Andersen, Allan M.;Pietrzak, Robert H.;Han, Shizhong
通讯作者：
Han, Shizhong
影响因子：
4.2
作者：
Agrawal, Arpana;Hinrichs, Anthony L.;Bierut, Laura J.
通讯作者：
Bierut, Laura J.
影响因子：
30.8
作者：
Bulik-Sullivan B;Finucane HK;Anttila V;Gusev A;Day FR;Loh PR;ReproGen Consortium;Psychiatric Genomics Consortium;Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3;Duncan L;Perry JR;Patterson N;Robinson EB;Daly MJ;Price AL;Neale BM
通讯作者：
Neale BM
影响因子：
30.8
作者：
Allen, Nicole C.;Bagade, Sachin;Bertram, Lars
通讯作者：
Bertram, Lars