Resting state functional MRI in infants with prenatal opioid exposure-a pilot study.
Resting state functional MRI in infants with prenatal opioid exposure-a pilot study.
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DOI：
10.1007/s00234-020-02552-3
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发表时间：
2021-04
期刊：
影响因子：
2.8
通讯作者：
中科院分区：
文献类型：
--
作者：
产前暴露于阿片类药物可能会对发育中的大脑网络产生不利影响。这项初步研究的目的是评估产前阿片类药物暴露的婴儿杏仁核功能连接的改变。在这项经IRB批准的前瞻性研究中，我们对10名产前暴露于阿片类药物的婴儿和12名校正胎龄<48周的未暴露于阿片类药物的婴儿进行了静息状态功能性MRI（rs-fMRI）。在标准的预处理之后，我们进行了基于种子的功能连接分析，在校正了母亲抑郁和婴儿性别之后，将右侧和左侧杏仁核作为感兴趣的区域。我们比较了有和没有产前阿片类药物暴露的婴儿之间杏仁核网络的功能连接。有显着差异的连接杏仁核种子区的几个皮层区域，包括内侧前额叶皮质的婴儿谁有产前阿片类药物暴露相比，阿片类药物初治婴儿。宫内阿片类药物暴露的婴儿杏仁核功能连接增加的这一发现表明母体阿片类药物暴露对婴儿杏仁核功能改变的潜在作用。这种与出生前接触的联系需要在今后更大规模的研究中加以复制。
Exposure to prenatal opioids may adversely impact the developing brain networks. The aim of this pilot study was to evaluate alterations in amygdalar functional connectivity in human infants with prenatal opioid exposure. In this prospective IRB approved study, we performed resting state functional MRI (rs-fMRI) in 10 infants with prenatal opioid exposure and 12 infants without prenatal drug exposure at <48 weeks corrected gestational age. Following standard pre-processing, we performed seed based functional connectivity analysis with the right and left amygdala as the regions of interest after correcting for maternal depression and infant sex. We compared functional connectivity of the amygdala network between infants with and without prenatal opioid exposure. There were significant differences in connectivity of the amygdala seed regions to the several cortical regions including the medial prefrontal cortex in infants who had prenatal opioid exposure when compared to opioid naïve infants. This finding of increased amygdala functional connectivity in infants with in-utero opioid exposure suggests a potential role of maternal opioid exposure on infants’ altered amygdala function. This association with pre-natal exposure needs to be replicated in future larger studies.
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影响因子：
2.9
作者：
Schweitzer JB;Riggins T;Liang X;Gallen C;Kurup PK;Ross TJ;Black MM;Nair P;Salmeron BJ
通讯作者：
Salmeron BJ
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
2.9
作者：
Nygaard, Egil;Slinning, Kari;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.
影响因子：
5.3
作者：
Treit, Sarah;Lebel, Catherine;Beaulieu, Christian
通讯作者：
Beaulieu, Christian
影响因子：
4.8
作者：
Smith, SM
通讯作者：
Smith, SM