Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection.
Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection.
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DOI：
10.4049/jimmunol.181.11.7985
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发表时间：
2008-12-01
影响因子：
4.4
通讯作者：
Carr, Daniel J. J.
中科院分区：
文献类型：
--
作者：
Wuest, Todd R.;Carr, Daniel J. J.
The chemokine, CXCL10, chemotactic for NK cells, activated T cells, and dendritic cells is highly expressed during viral infections, including HSV-1. The importance of this chemokine to the control of HSV-1 infection was tested using mice deficient in CXCL10 (CXCL10 −/−). Following corneal infection, HSV-1 viral titers were elevated in the nervous system of CXCL10 −/− mice which correlated with defects in leukocyte recruitment including dendritic cells, NK cells, and HSV-1 specific CD8+ T cell to the brain stem. In the absence of NK cells and HSV-1 specific CD8+ T cells in wild type (WT) or CXCL10−/− mice, similar levels of virus were recovered in the nervous system suggesting these cells are responsible for the observed defects in the control of viral replication in CXCL10 −/− mice. Leukocyte mobilization was also compared between WT, CXCL10 −/−, and mice deficient in the only known receptor for CXCL10, CXCR3 (CXCR3 −/−). NK cell mobilization was comparably reduced in both CXCL10 −/− and CXCR3 −/− mice relative to WT animals. However, the reduction in mobilization of HSV-1 specific CD8+ T cells in CXCL10 −/− was not observed in CXCR3 −/− mice following HSV-1 infection. The defect was not the result of an alternative receptor for CXCL10, as antigen-specific CD8+ T cell recruitment was not reduced in mice which were deficient in both CXCL10 and CXCR3. Thus, CXCL10 deficiency results in reduced mobilization of HSV-1 specific CD8+ T cells as a result of dysregulation of CXCR3 signaling.
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影响因子：
4.4
作者：
Christensen, Jeanette Erbo;de Lemos, Carina;Thomsen, Allan Randrup
通讯作者：
Thomsen, Allan Randrup
影响因子：
5.4
作者：
HANKE, T;GRAHAM, FL;JOHNSON, DC
通讯作者：
JOHNSON, DC
DOI：
10.1084/jem.192.10.1515
发表时间：
2000-11-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hancock WW;Lu B;Gao W;Csizmadia V;Faia K;King JA;Smiley ST;Ling M;Gerard NP;Gerard C
通讯作者：
Gerard C
影响因子：
4.4
作者：
Campanella, Gabriele S. V.;Grimm, Jan;Luster, Andrew D.
通讯作者：
Luster, Andrew D.
影响因子：
64.8
作者：
Baggiolini, M
通讯作者：
Baggiolini, M