Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium.
Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium.
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DOI：
10.1111/j.1365-2982.2012.01894.x
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发表时间：
2012-06
影响因子：
3.5
通讯作者：
NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
中科院分区：
文献类型：
--
作者：
Grover M;Bernard CE;Pasricha PJ;Lurken MS;Faussone-Pellegrini MS;Smyrk TC;Parkman HP;Abell TL;Snape WJ;Hasler WL;McCallum RW;Nguyen L;Koch KL;Calles J;Lee L;Tonascia J;Ünalp-Arida A;Hamilton FA;Farrugia G;NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
最近，在胃轻瘫临床研究联盟中招募的患者中描述了与糖尿病（DG）和特发性胃轻瘫（IG）相关的细胞变化。这些细胞变化与胃轻瘫症状和胃排空的关系尚不清楚。胃轻瘫患者的细胞变化与症状和胃排空的关系。早些时候，使用全层胃体活检从20 DG，20 IG和20匹配的控制，我们发现减少的Cajal间质细胞（ICC）和肠神经和增加免疫细胞在DG和IG。在这里，人口统计学，症状（胃轻瘫主要症状指数评分），胃排空与细胞的变化使用皮尔逊相关系数。在DG中，ICC计数与4小时胃潴留呈负相关，而在IG中则不相关（r=-0.6，p=0.008，DG; r=0.2，p=0.4，IG）。在DG中，ICC损失与肠神经之间也存在显著相关性，但在IG中不存在（DG的r=0.5，p=0.03，IG的r=0.3，p=0.16）。与没有浸润的IG相比，具有肌间免疫浸润的IG的平均GCSI评分（3.6±0.7 vs 2.7±0.9，p=0.05）和恶心评分（3.8±0.9 vs 2.6±1.0，p=0.02）更高。在DG中，ICC的丧失与胃排空延迟相关。ICC或肠神经丧失与症状严重程度无关。IG的总体临床严重程度和恶心与肌间免疫浸润相关。因此，全层胃活检可以帮助确定胃轻瘫的特定细胞异常，其中一些与胃轻瘫的生理和临床特征相关。
Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. Relate cellular changes to symptoms and gastric emptying in patients with gastroparesis. Earlier, using full thickness gastric body biopsies from 20 DG, 20 IG and 20 matched controls, we found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both DG and IG. Here, demographic, symptoms (gastroparesis cardinal symptom index score), and gastric emptying were related to cellular alterations using Pearson’s correlation coefficients. ICC counts inversely correlated with 4 hours gastric retention in DG but not in IG (r=−0.6, p=0.008, DG, r=0.2, p=0.4, IG). There was also a significant correlation between loss of ICC and enteric nerves in DG but not in IG (r=0.5, p=0.03 for DG, r=0.3, p=0.16, IG). IG with a myenteric immune infiltrate scored higher on the average GCSI (3.6±0.7 vs 2.7±0.9, p=0.05) and nausea score (3.8±0.9 vs 2.6±1.0, p=0.02) as compared to those without an infiltrate. In DG, loss of ICC is associated with delayed gastric emptying. ICC or enteric nerve loss did not correlate with symptom severity. Overall clinical severity and nausea in IG is associated with a myenteric immune infiltrate. Thus, full thickness gastric biopsies can help define specific cellular abnormalities in gastroparesis, some of which are associated with physiological and clinical characteristics of gastroparesis.
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影响因子：
29.4
作者：
Parkman HP;Yates K;Hasler WL;Nguyen L;Pasricha PJ;Snape WJ;Farrugia G;Koch KL;Abell TL;McCallum RW;Lee L;Unalp-Arida A;Tonascia J;Hamilton F;National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
通讯作者：
National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
影响因子：
5
作者：
PLOURDE, V;QUINTERO, E;TACHE, Y
通讯作者：
TACHE, Y
影响因子：
3.5
作者：
Miller, S. M.;Narasimhan, R. A.;Farrugia, G.
通讯作者：
Farrugia, G.
影响因子：
2.4
作者：
Pasricha PJ;Pehlivanov ND;Gomez G;Vittal H;Lurken MS;Farrugia G
通讯作者：
Farrugia G
影响因子：
29.4
作者：
Grover M;Farrugia G;Lurken MS;Bernard CE;Faussone-Pellegrini MS;Smyrk TC;Parkman HP;Abell TL;Snape WJ;Hasler WL;Ünalp-Arida A;Nguyen L;Koch KL;Calles J;Lee L;Tonascia J;Hamilton FA;Pasricha PJ;NIDDK Gastroparesis Clinical Research Consortium
通讯作者：
NIDDK Gastroparesis Clinical Research Consortium