Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity.
Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity.
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DOI：
10.1053/j.gastro.2010.10.015
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发表时间：
2011-01
期刊：
影响因子：
29.4
通讯作者：
National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
中科院分区：
文献类型：
--
作者：
Parkman HP;Yates K;Hasler WL;Nguyen L;Pasricha PJ;Snape WJ;Farrugia G;Koch KL;Abell TL;McCallum RW;Lee L;Unalp-Arida A;Tonascia J;Hamilton F;National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
特发性胃轻瘫（IG）是一种常见但鲜为人知的疾病，发病率很高。我们研究了在NIDDK胃轻瘫临床研究联盟登记处登记的IG患者的特征。从IG患者的病史、症状问卷和4小时胃排空显像研究中获得数据。243例IG患者的平均年龄为41岁；88%为女性，46%为超重，50%有急性发作症状，19%报告有最初的感染前驱症状。28%的患者出现胃排空严重延迟（4小时内滞留35%）。主要症状为恶心（34%）、呕吐（19%）和腹痛（23%）。女性有更严重的恶心、饱腹感、便秘和整体胃轻瘫症状。急性发作性IG患者的恶心程度比潜伏性IG患者更严重。超重患者在2小时时有更多的腹胀和胃潴留，但食欲减退较轻。胃排空严重延迟的患者有更严重的呕吐、更严重的食欲不振和整体胃轻瘫症状。严重焦虑和抑郁分别占36%和18%。86%符合功能性消化不良的标准，主要是餐后焦虑综合征。IG是一种主要影响年轻女性的疾病，50%的病例以急性开始；出乎意料的是，很多患者都超重了。胃排空严重延迟与更严重的呕吐和食欲不振症状相关。IG是一种多样的综合征，因性别、体重、症状发作和胃排空延迟而异。
Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the NIDDK Gastroparesis Clinical Research Consortium Registry. Data from medical histories, symptom questionnaires, and 4-hour gastric emptying scintigraphy studies were obtained from patients with IG. The mean age of 243 IG patients studied was 41 years; 88% were female, 46% were overweight, 50% had acute onset of symptoms, and 19% reported an initial infectious prodrome. Severe delay in gastric emptying (>35% retention at 4 hours) was present in 28% of patients. Predominant presenting symptoms were nausea (34%), vomiting (19%), and abdominal pain (23%). Women had more severe nausea, satiety, constipation and overall gastroparesis symptoms. Patients who experienced acute onset IG had worse nausea than those with insidious onset. Overweight patients had more bloating and gastric retention at 2 hours, but less severe loss of appetite. Patients with severely delayed gastric emptying had worse vomiting, more severe loss of appetite and overall gastroparesis symptoms. Severe anxiety and depression was present in 36% and 18%, respectively. 86% met criteria for functional dyspepsia, primarily postprandial distress syndrome. IG is a disorder that primarily affects young women, beginning acutely in 50% of cases; unexpectedly, many patients are overweight. Severe delay in gastric emptying was associated with more severe symptoms of vomiting and loss of appetite. IG is a diverse syndrome that varies by sex, body mass, symptom onset, and delay in gastric emptying.
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影响因子：
12.6
作者：
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通讯作者：
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