Neurobiology of the incubation of drug craving.
Neurobiology of the incubation of drug craving.
复制标题
渴望孵化的神经生物学。
DOI：
10.1016/j.tins.2011.06.001
复制
发表时间：
2011-08
影响因子：
15.9
通讯作者：
Shaham, Yavin
中科院分区：
文献类型：
--
作者：
Pickens, Charles L.;Airavaara, Mikko;Theberge, Florence;Fanous, Sanya;Hope, Bruce T.;Shaham, Yavin
1986年有人提出，可卡因成瘾者在戒断的最初几周内，由线索引起的对毒品的渴望会逐渐增加，并在较长时间内保持这种渴望。在过去的十年中，研究人员在啮齿动物中发现了类似的潜伏期现象，在停止静脉注射可卡因后，观察到线索诱导的药物寻找的时间依赖性增加。这种对毒品的渴望并不是可卡因所特有的，因为在大鼠自我服用海洛因、尼古丁、甲基苯丙胺和酒精后也观察到类似的结果。在这篇综述中，我们讨论了最近的研究结果，这些结果已经确定了参与药物渴望孵化的重要大脑区域，以及潜在细胞机制的证据。了解啮齿类动物药物渴望潜伏期的神经生物学，可能对我们进一步了解人类成瘾者药物渴望背后的大脑机制和回路具有重要意义。
It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively increases over the first several weeks of abstinence and remains high for extended periods. During the last decade, investigators have identified an analogous incubation phenomenon in rodents, in which time-dependent increases in cue-induced drug seeking are observed after withdrawal from intravenous cocaine self-administration. Such an incubation of drug craving is not specific to cocaine, as similar findings have been observed after self-administration of heroin, nicotine, methamphetamine, and alcohol in rats. In this review, we discuss recent results that have identified important brain regions involved in the incubation of drug craving, as well as evidence for the underlying cellular mechanisms. Understanding the neurobiology of the incubation of drug craving in rodents is likely to have significant implications for furthering our understanding of brain mechanisms and circuits that underlie drug craving in human addicts.
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影响因子：
3.4
作者：
Bossert, Jennifer M.;Wihbey, Kristina A.;Pickens, Charles L.;Nair, Sunila G.;Shaham, Yavin
通讯作者：
Shaham, Yavin
DOI：
10.1038/npp.2009.187
发表时间：
2010-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
25
作者：
Bossert, Jennifer M.;Stern, Anna L.;Theberge, Florence R. M.;Cifani, Carlo;Koya, Eisuke;Hope, Bruce T.;Shaham, Yavin
通讯作者：
Shaham, Yavin
影响因子：
5.6
作者：
Bienkowski, P;Rogowski, A;Kostowski, W
通讯作者：
Kostowski, W
影响因子：
7.6
作者：
Freeman, Willard M.;Patel, Kruti M.;Vrana, Kent E.
通讯作者：
Vrana, Kent E.