Intact motivated attention in schizophrenia: evidence from event-related potentials.
Intact motivated attention in schizophrenia: evidence from event-related potentials.
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DOI：
10.1016/j.schres.2011.11.005
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发表时间：
2012-03
影响因子：
4.5
通讯作者：
Green, Michael F.
中科院分区：
文献类型：
--
作者：
Horan, William P.;Foti, Dan;Hajcak, Greg;Wynn, Jonathan K.;Green, Michael F.
情感上重要的刺激通常会吸引注意力（称为动机性注意力），即使它们与注意力所指向的任务无关。先前的研究表明，当精神分裂症受试者被指示参加情绪唤起刺激时，情绪处理的几个组成部分是完整的。然而，很少有研究调查当精神分裂症患者的注意力被转移到其他地方时，情绪刺激是否能正常地吸引他们的注意力。本研究采用改进的视觉P300奇球检测任务，对35名稳定的门诊病人和26名健康对照进行了事件相关电位的动机性注意检测。参与者观看罕见的目标图像和常见的标准字母刺激图像，以及混合情绪（不愉快的，愉快的，中性的）图像。受试者被要求计算稀有目标的数量；因此，图片刺激的情绪效价与任务无关。我们分别评估了情绪图片的早期后验负性（EPN）和后期正电位（LPP）以及目标刺激的P300。患者和对照组对情绪刺激表现出相似的EPN和LPP振幅模式，例如愉快和不愉快的EPN和LPP都比中性图片大。尽管患者在目标计数任务中的表现比对照组差，但两组在目标刺激和非目标刺激之间都表现出相似的P300分化。在精神分裂症患者中，即使情绪刺激与任务无关，情绪刺激也能捕获注意力资源，这表明在早期电生理反应水平上，完整的动机性注意是存在的。
Emotionally significant stimuli typically capture attention (called motivated attention) even when they are irrelevant to tasks where attention is directed. Previous studies indicate that several components of emotional processing are intact in schizophrenia when subjects are instructed to attend to emotionally-evocative stimuli. However, few studies have examined whether emotional stimuli capture attention to a normal degree in people with schizophrenia when attention is directed elsewhere. The current event-related potential study examined motivated attention to task-irrelevant emotional stimuli in 35 stabilized outpatients and 26 healthy controls with a modified visual P300 oddball detection task. Participants viewed images of rare target and commonly occurring standard letter stimuli, as well as intermixed emotional (unpleasant, pleasant, neutral) pictures. Subjects were instructed to count the number of rare targets; the emotional valence of the picture stimuli was, therefore, task-irrelevant. We separately evaluated the Early Posterior Negativity (EPN) and Late Positive Potential (LPP) to emotional pictures and the P300 to target stimuli. Patients and controls showed similar patterns of EPN and LPP amplitude to the emotional stimuli, such that the EPN and LPP were larger for both pleasant and unpleasant versus neutral pictures. Although patients performed worse than controls on the target counting task, both groups showed comparable P300 differentiation between target versus non-target stimuli. Emotional stimuli captured attentional resources in people with schizophrenia even when the emotional stimuli were task-irrelevant, suggesting intact motivated attention at the level of early electrophysiological responding.
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