The role of decision-making ability in HIV/AIDS: impact on prospective memory.
The role of decision-making ability in HIV/AIDS: impact on prospective memory.
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DOI：
10.1080/13803395.2014.935705
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发表时间：
2014
影响因子：
2.2
通讯作者：
Mindt MR
中科院分区：
文献类型：
--
作者：
Coulehan K;Byrd D;Arentoft A;Monzones J;Fuentes A;Fraser F;Rosario A;Morgello S;Mindt MR
前瞻性记忆（Prospective Memory，ProM）是一种与执行未来意图相关的情景记忆，对日常功能非常重要。在艾滋病毒感染者（PLWH）中，执行功能障碍与ProM损伤有关。然而，参与ProM赤字的执行功能的具体子组件仍然知之甚少。与更“传统”的神经认知（NC）测量与背外侧前额叶皮质相关的执行功能不同（即，概念推理、抽象），与内侧眶额/腹内侧前额叶（mOF/vmP）皮层相关的那些（即，决策，抑制控制，目标导向行为）尚未在ProM中进行检查。本研究的特点ProM能力的样本中的89艾滋病毒血清阳性的成年人，并研究了独特的作用，决策能力的ProM。参与者完成了一个标准的NC电池，爱荷华州赌博任务（IGT;决策措施），和意图筛选测试（MIST; ProM措施）的记忆。相关分析显示，传统的执行功能的措施和IGT与ProM。回归分析显示，IGT显着预测ProM，即使在占NC措施。在所有NC措施中，只有执行功能显着贡献ProM。需要进一步检查该人群中的mOF/vmP敏感性执行功能障碍，因为PLWH可能需要更有针对性的治疗建议，因为特定的决策困难可能会影响药物管理。
Prospective memory (ProM), a form of episodic memory related to execution of future intentions, is important for everyday functioning. Among persons living with HIV (PLWH), executive dysfunction is implicated in ProM impairments. However, specific subcomponents of executive functioning involved in ProM deficits remain poorly understood. Unlike more “traditional” neurocognitive (NC) measures of executive functioning associated with dorsolateral prefrontal cortex (i.e., conceptual reasoning, abstraction), those associated with medial orbitofrontal/ventromedial prefrontal (mOF/vmP) cortex (i.e., decision making, inhibitory control, goal-oriented behavior) have yet to be examined in ProM. This study characterized ProM ability in a sample of 89 HIV-seropositive adults and examined the unique role of decision-making ability in ProM. Participants completed a standard NC battery, the Iowa Gambling Task (IGT; a decision-making measure), and the Memory for Intentions Screening Test (MIST; a ProM measure). Correlational analyses revealed that both traditional executive functioning measures and the IGT were associated with ProM. Regression analyses revealed that the IGT significantly predicted ProM, even after accounting for NC measures. Among all NC measures, only executive functioning significantly contributed to ProM. Further examination of mOF/vmP-sensitive executive dysfunction within this population is needed as PLWH may require more tailored treatment recommendations due to specific decision-making difficulties that can impact medication management.
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影响因子：
3.7
作者：
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通讯作者：
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DOI：
10.1017/s1355617704102130
发表时间：
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影响因子：
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作者：
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通讯作者：
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