The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
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DOI：
10.1016/j.cbi.2008.10.040
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发表时间：
2009-03-16
影响因子：
5.1
通讯作者：
Oppermann, Udo
中科院分区：
文献类型：
--
作者：
Persson, Bengt;Kallberg, Yvonne;Bray, James E.;Bruford, Elspeth;Dellaporta, Stephen L.;Favia, Angelo D.;Gonzalez Duarte, Roser;Jornvall, Hans;Kavanagh, Kathryn L.;Kedishvili, Natalia;Kisiela, Michael;Maserk, Edmund;Mindnich, Rebekka;Orchard, Sandra;Penning, Trevor M.;Thornton, Janet M.;Adamski, Jerzy;Oppermann, Udo
短链脱氢酶/还原酶（SDR）是最大的酶超家族之一，目前有超过46000个成员。在系统发育比较中，这个超家族的成员显示出早期的分化，尽管具有共同的结构特性，但大多数成员只有低成对序列同一性。SDR酶几乎存在于所有被研究的基因组中，在人类中已经鉴定出超过70个SDR基因。在人类中，这些酶参与多种化合物的代谢，包括类固醇激素、前列腺素、类维生素a、脂质和异种生物。现在很清楚，特别提款权代表了最古老的蛋白质家族之一，并有助于所有形式的生命的基本功能和相互作用。随着这一领域的快速发展，系统的命名法对于将来的注释和参考是必不可少的。基于隐马尔可夫模型的SDR超族的功能细分为至少200个SDR族，形成了这样一个命名系统的合适基础，我们在本文中以人类SDR为例。
Short-chain dehydrogenases/reductases (SDR) constitute one of the largest enzyme superfamilies with presently over 46 000 members. In phylogenetic comparisons, members of this superfamily show early divergence where the majority have only low pair-wise sequence identity, although sharing common structural properties. The SDR enzymes are present in virtually all genomes investigated, and in humans over 70 SDR genes have been identified. In humans, these enzymes are involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. It is now clear that SDRs represent one of the oldest protein families and contribute to essential functions and interactions of all forms of life. As this field continues to grow rapidly, a systematic nomenclature is essential for future annotation and reference purposes. A functional subdivision of the SDR superfamily into at least 200 SDR families based upon hidden Markov models forms a suitable foundation for such a nomenclature system, which we present in this paper using human SDRs as examples.
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影响因子：
3.7
作者：
Williamson SJ;Rusch DB;Yooseph S;Halpern AL;Heidelberg KB;Glass JI;Andrews-Pfannkoch C;Fadrosh D;Miller CS;Sutton G;Frazier M;Venter JC
通讯作者：
Venter JC
影响因子：
14.9
作者：
Mulder NJ;Apweiler R;Attwood TK;Bairoch A;Bateman A;Binns D;Bork P;Buillard V;Cerutti L;Copley R;Courcelle E;Das U;Daugherty L;Dibley M;Finn R;Fleischmann W;Gough J;Haft D;Hulo N;Hunter S;Kahn D;Kanapin A;Kejariwal A;Labarga A;Langendijk-Genevaux PS;Lonsdale D;Lopez R;Letunic I;Madera M;Maslen J;McAnulla C;McDowall J;Mistry J;Mitchell A;Nikolskaya AN;Orchard S;Orengo C;Petryszak R;Selengut JD;Sigrist CJ;Thomas PD;Valentin F;Wilson D;Wu CH;Yeats C
通讯作者：
Yeats C
影响因子：
14.9
作者：
Bairoch, Amos;Bougueleret, Lydie;Zhang, Jian
通讯作者：
Zhang, Jian
影响因子：
14.9
作者：
Chenna, R;Sugawara, H;Thompson, JD
通讯作者：
Thompson, JD
影响因子：
14.9
作者：
Pruitt KD;Tatusova T;Maglott DR
通讯作者：
Maglott DR