Direct dorsal hippocampal-prelimbic cortex connections strengthen fear memories.
Direct dorsal hippocampal-prelimbic cortex connections strengthen fear memories.
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DOI：
10.1038/nn.4443
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发表时间：
2017-01
影响因子：
25
通讯作者：
Alberini, Cristina M.
中科院分区：
文献类型：
--
作者：
Ye, Xiaojing;Kapeller-Libermann, Dana;Travaglia, Alessio;Inda, M. Carmen;Alberini, Cristina M.
调节对威胁性经历的记忆的巩固和加强的能力对心理健康至关重要，其失调可能导致精神病理学。再次暴露于经历过威胁的环境中可以通过不同的过程增加或减少恐惧反应，分别称为重新巩固或灭绝。使用上下文检索依赖的记忆增强大鼠的范例，我们报告说，通过激活直接从背侧海马（dHC）的前边缘（PL）皮质和关键PL分子机制，这是不需要灭绝的投射，记忆加强。此外，虽然持续的PL BDNF表达是记忆巩固所必需的，但检索使PL BDNF参与调节兴奋性和抑制性突触蛋白neuroligin 1和neuroligin 2，其促进记忆强化，同时抑制消退。因此，上下文检索介导的恐惧记忆增强是通过重新巩固记忆同时抑制消退的机制的协同作用的结果。
The ability to regulate the consolidation and strengthening of memories for threatening experiences is critical for mental health, and its dysregulation may lead to psychopathologies. Re-exposure to the context in which the threat was experienced can either increase or decrease fear response through distinct processes known, respectively, as reconsolidation or extinction. Using a context retrieval-dependent memory enhancement paradigm in rats, we report that memory strengthens through the activation of direct projections from the dorsal hippocampus (dHC) to the prelimbic (PL) cortex and of critical PL molecular mechanisms, which are not required for extinction. Furthermore, while a sustained PL BDNF expression is required for memory consolidation, retrieval engages PL BDNF to regulate the excitatory and inhibitory synaptic proteins neuroligin 1 and neuroligin 2, which promote memory strengthening while inhibiting extinction. Thus, context retrieval-mediated fear memory enhancement results from a concerted action of mechanisms that strengthen memory through reconsolidation while suppressing extinction.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
15.9
作者：
Korb E;Finkbeiner S
通讯作者：
Finkbeiner S
通过重新整合通过检索来增强恐惧记忆。
影响因子：
7.7
作者：
Fukushima H;Zhang Y;Archbold G;Ishikawa R;Nader K;Kida S
通讯作者：
Kida S
影响因子：
25
作者：
Gu, Jiaping;Lee, Chi Wai;Fan, Yanjie;Komlos, Daniel;Tang, Xin;Sun, Chicheng;Yu, Kuai;Hartzell, H. Criss;Chen, Gong;Bamburg, James R.;Zheng, James Q.
通讯作者：
Zheng, James Q.
影响因子：
56.9
作者：
Berman, DE;Dudai, Y
通讯作者：
Dudai, Y