The 3-second rule in hereditary pure cerebellar ataxia: a synchronized tapping study.
The 3-second rule in hereditary pure cerebellar ataxia: a synchronized tapping study.
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DOI：
10.1371/journal.pone.0118592
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Terao Y
中科院分区：
文献类型：
--
作者：
Matsuda S;Matsumoto H;Furubayashi T;Hanajima R;Tsuji S;Ugawa Y;Terao Y
“3秒规则”是基于各种各样的观察而提出的，即大约3秒的时间段构成了与正常人的神经认知机制相关的基本时间单位。本研究的目的是采用同步敲击任务研究脊髓小脑性共济失调6型（SCA6）和SCA31（纯小脑型脊髓小脑变性）患者的时间加工。17名SCA患者（11名SCA6，6名SCA31）和17名正常年龄匹配的志愿者参加了研究。该任务要求受试者敲击键盘同步序列的听觉刺激，在固定的刺激间隔（ISI）之间的200和4800毫秒。在这项任务中，受试者需要非电机组件来估计的时间即将到来的音调，除了电机组件点击。正常受试者同步他们的水龙头在较短的ISI呈现的音调，而随着ISI变得更长，正常受试者显示更大的潜伏期之间的音调和水龙头（过渡区）。在过渡区之后，正常受试者按下的按钮相对于音调延迟。另一方面，SCA患者即使在较短的ISI下也不能使他们的敲击与音调同步，尽管他们比正常受试者更早地按下相对于音调延迟的按钮。正常人移行区后延迟叩击出现的最早时间为4800 ms，而SCA患者为1800 ms。与正常人相比，SCA患者的时间整合广度缩短。这可能代表SCA患者的非运动性小脑功能障碍。
The ‘3-second rule’ has been proposed based on miscellaneous observations that a time period of around 3 seconds constitutes the fundamental unit of time related to the neuro-cognitive machinery in normal humans. The aim of paper was to investigate the temporal processing in patients with spinocerebellar ataxia type 6 (SCA6) and SCA31, pure cerebellar types of spinocerebellar degeneration, using a synchronized tapping task. Seventeen SCA patients (11 SCA6, 6 SCA31) and 17 normal age-matched volunteers participated. The task required subjects to tap a keyboard in synchrony with sequences of auditory stimuli presented at fixed interstimulus intervals (ISIs) between 200 and 4800 ms. In this task, the subjects required non-motor components to estimate the time of forthcoming tone in addition to motor components to tap. Normal subjects synchronized their taps to the presented tones at shorter ISIs, whereas as the ISI became longer, the normal subjects displayed greater latency between the tone and the tapping (transition zone). After the transition zone, normal subjects pressed the button delayed relative to the tone. On the other hand, SCA patients could not synchronize their tapping with the tone even at shorter ISIs, although they pressed the button delayed relative to the tone earlier than normal subjects did. The earliest time of delayed tapping appearance after the transition zone was 4800 ms in normal subjects but 1800 ms in SCA patients. The span of temporal integration in SCA patients is shortened compared to that in normal subjects. This could represent non-motor cerebellar dysfunction in SCA patients.
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